ADAM9
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Official Full Name
ADAM metallopeptidase domain 9 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
ADAM9;ADAM metallopeptidase domain 9;MCMP;MDC9;CORD9;Mltng;disintegrin and metalloproteinase domain-containing protein 9;cone rod dystrophy 9;myeloma cell metalloproteinase;cellular disintegrin-related protein;ADAM metallopeptidase domain 9 (meltrin gamma);metalloprotease/disintegrin/cysteine-rich protein 9
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mouse
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAM9-1386Z | Recombinant Zebrafish ADAM9 | Mammalian Cell | Zebrafish | His |
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| ADAM9-293H | Recombinant Human ADAM9 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ADAM9-3005H | Recombinant Human ADAM9, His-tagged | E.coli | Human | His | 819 |
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| ADAM9-3047C | Recombinant Chicken ADAM9 | Mammalian Cell | Chicken | His |
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| Adam9-830M | Recombinant Mouse Adam9 Protein, His-tagged | HEK293 | Mouse | His | 1-697 a.a. |
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| ADAM9-1750MCL | Recombinant Mouse ADAM9 cell lysate | Human Cell | Mouse | Non |
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| ADAM9-0245H | Recombinant Human ADAM9 Protein (Pro440-Gly680), N-His-tagged | E.coli | Human | His | Pro440-Gly680 |
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| ADAM9-1900C | Recombinant Cynomolgus ADAM9 protein, His-tagged | HEK293 | Cynomolgus | His | Ala 206 - Asp 697 |
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| ADAM9-2422H | Recombinant Human ADAM9 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ADAM9-2422H-B | Recombinant Human ADAM9 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| ADAM9-311H | Active Recombinant Human ADAM9 Protein, His-tagged | Mammalian cells | Human | His | 206-697 a.a. |
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Involved Pathway
ADAM9 involved in several pathways and played different roles in them. We selected most pathways ADAM9 participated on our site, such as Collagen degradation,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | CTSG,CTSD,MMP11,MATN3B,ITGB3A,MATN3,LRP4,TRAPPC4,TIMP2A,BMP10 |
| Degradation of the extracellular matrix | COL9A1,COL9A3,CTSL1,ADAMTS5,COL15A1B,EMID2,TLDC2,CTSB,FURINA,ACAN |
| Collagen degradation | ADAM10,COL17A1,MMP10,TLDC2,COL19A1,LOC100686744,MMP20,MGC174155,COL9A1,MMP19 |
Protein Function
ADAM9 has several biochemical functions, for example, SH3 domain binding,collagen binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM9 itself. We selected most functions ADAM9 had, and list some proteins which have the same functions with ADAM9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase C binding | AKT1,PLEK,HDAC7,NELL2,TIRAP,HAND2,DACT1,FLNA,HDAC7A,TRPV4 |
| zinc ion binding | RBM10,ZMIZ1A,KMT2E,TRAF4A,GM3258,MORC3A,PPARAA,WBP7,RORAA,PDLIM7 |
| collagen binding | ITGA9,TGFBI,CTSL1,ANTXR1,PODN,Itga10&Itgb1,SMAD3,LACRT,VWF,USH2A |
| metallopeptidase activity | MMP14B,TAF2,TMEM27,ADAM17,AMZ2,CLCA2,ACE,ADAM10,ADAM25,Npepo |
| SH3 domain binding | QKIA,CNTNAP1,CBLC,ARHGAP31,VASP,CASP9,SH3BP5LA,USP8,KHDRBS2,LYN |
| laminin binding | GPC1,LYPD3,LYPD5,ITGA7,LRRC15,NCL,THBS1,PLEKHA2,BCAM,ITGA9 |
| protein binding | ORM1,UNC13D,SKIV2L2,RABGAP1,MKL1,HORMAD1,NFYC,IFT57,SOCS3,TNFRSF10B |
| integrin binding | WISP2,ECM2,ICAM3,FAP,TGFBI,CYR61,SFRP2,ADAMTS13,FERMT3,ICAM1 |
| metalloendopeptidase activity | HE2,ADAM10,MMP19,ADAMTS18,ADAMTS9,Adamts19,NRD1B,C6AST3,THSD4,ADAM17A |
Interacting Protein
ADAM9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM9.
MAD2L2;SH3GL2;PACSIN3;KIF2C
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References
- Kim, JM; Jeung, HC; et al. The Effect of Disintegrin-Metalloproteinase ADAM9 in Gastric Cancer Progression. MOLECULAR CANCER THERAPEUTICS 13:3074-3085(2014).
- Webber, J; Stone, TC; et al. Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscan(TM)) Platform*. MOLECULAR & CELLULAR PROTEOMICS 13:1050-1064(2014).
