ADAM2
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Official Full Name
ADAM metallopeptidase domain 2 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. -
Synonyms
ADAM2;ADAM metallopeptidase domain 2;fertilin beta , FTNB;disintegrin and metalloproteinase domain-containing protein 2;cancer/testis antigen 15;CT15;PH 30b;PH30;A disintegrin and metalloproteinase domain 2;ADAM 2;ADAM2_HUMAN;AI323749;CRYN1;CRYN2;Fertilin beta;Fertilin subunit beta;Ftnb;PH 30;PH-30;Ph30 beta;PH30-beta;OTTHUMP00000225677;OTTHUMP00000225678;OTTHUMP00000225679;OTTHUMP00000225680;PH-30b
Recombinant Proteins
- Mouse
- Cynomolgus
- Human
- Rat
- Bovine
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ADAM2 involved in several pathways and played different roles in them. We selected most pathways ADAM2 participated on our site, such as Fertilization,Interaction With The Zona Pellucida,Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fertilization | IZUMO1,HVCN1,ADAM30,OVGP1,CATSPER2,TMEM146,ADAM21,CATSPER3,IZUMO4,ZP3 |
| Interaction With The Zona Pellucida | ADAM30,ADAM20,ADAM21,ZP3,ZP2,OVGP1 |
| Reproduction | ADAM20,TMEM146,CATSPERG1,ADAM21,OVGP1,IZUMO4,CATSPERB,CATSPER3,CATSPERG2,CATSPER2 |
Protein Function
ADAM2 has several biochemical functions, for example, integrin binding,metalloendopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM2 itself. We selected most functions ADAM2 had, and list some proteins which have the same functions with ADAM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | SIRT2,SF3A2,ENPP2,CA3,RNF2,TRIM35-21,CREBBP,ZFP276,CPXM2,LNX2 |
| metallopeptidase activity | BRCC3,PAPPA2,AFG3L2,ADAM12,MMP25,DPEP3,ADAM15,GM5136,CLCA4,ADAM10B |
| metalloendopeptidase activity | MMP15,NLN,C6AST3,MMP30,MMEL1,ADAMTS5,ADAM33,C6AST4,Adam6,C6AST1 |
| integrin binding | COL3A1,S1PR3,ICAM4,SEMA7A,ADAMTS5,THY1,LAMB1,PXN,GFAP,CYR61L1 |
Interacting Protein
ADAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM2.
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References
- Desiderio, UV; Zhu, XL; et al. ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing alpha(4)/alpha(9) (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization. PLOS ONE 5:-(2010).
- Murase, SI; Cho, C; et al. ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. EUROPEAN JOURNAL OF NEUROSCIENCE 27:1585-1595(2008).
