ACO1
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Official Full Name
aconitase 1, soluble -
Overview
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs).IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA.The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA.Thus, IREB1 plays a central role in cellular iron homeostasis.It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. -
Synonyms
ACO1;aconitase 1, soluble;IREB1;cytoplasmic aconitate hydratase;IREBP;IRP1;IRE-BP 1;aconitate hydratase;citrate hydro-lyase;iron regulatory protein 1;ferritin repressor protein;iron-responsive element binding protein 1;iron-responsive element-
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cells
- Insect Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ACO1 involved in several pathways and played different roles in them. We selected most pathways ACO1 participated on our site, such as Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | SDHA,DLST,FH,OGDH,MDH1AA,OGDHL,DLD,SDHD,PDHA1A,PCXB |
| Metabolic pathways | TYRP1B,NDUFA12,NME7,PNLIPRP2,PCYT1AB,PYGMA,CYP2C39,NT5C2A,FDFT1,CYP2C38 |
| Glyoxylate and dicarboxylate metabolism | ACAT1,DLDH,AGXTA,GCSH,ACO2,GRHPRA,GLULC,DHDPSL,AGXT,SHMT1 |
| -Oxocarboxylic acid metabolism | GOT1,ACY1,IDH3G,GPT,AADAT,IDH1,BCAT2,IDH2,IDH3B,ACO2 |
| Carbon metabolism | MDH2,TPI1B,ME1,OGDHA,ACADM,HIBCH,SDHDA,PGAM1B,PGLS,MTHFR |
| Biosynthesis of amino acids | AADAT,IDH3G,ENO1,ASS1,BCAT2,PRPS1B,CPS1,PGAM1,TAT,CBSB |
Protein Function
ACO1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,RNA binding,aconitate hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACO1 itself. We selected most functions ACO1 had, and list some proteins which have the same functions with ACO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aconitate hydratase activity | ACO2 |
| metal ion binding | VEPH1,ZHX1,BIRC5,GGPS1,CD209,ZUFSP,ZBTB12,NEK9,SMAD1,LIG1 |
| protein binding | JAKMIP2,RAP1GAP,MAP4K2,WAS,TSC22D4,DOT1L,UNC45B,INMT,IRS4,VPS33B |
| 4 iron, 4 sulfur cluster binding | IREB2,RTEL1,BRIP1,NUBP2,NUBPL,NUBP1,CDKAL1,NDUFV1,ISCUB,ISCA1 |
| iron-responsive element binding | FECH,IREB2 |
| RNA binding | OASL2,ZNF385B,PKZ,RPL39L,CSTF2,IMPDH1,TRDMT1,RPL6,LSM5,EXOSC5 |
Interacting Protein
ACO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACO1.
NEB;SGCG;CCDC69;PXN;CLTC;MYBPC1;pbpG;ligB;YBX1
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References
- Binnie, IE; McManus, MT; et al. Characterization of the 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase multigene family of Malus domestica Borkh. PHYTOCHEMISTRY 70:348-360(2009).
- Pitula, JS; Deck, KM; et al. Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101:10907-10912(2004).
