ACER1
-
Official Full Name
alkaline ceramidase 1 -
Overview
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum;corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can;trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and;sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers;regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at;the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is;highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine;(Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)). -
Synonyms
ACER1;alkaline ceramidase 1;ASAH3, N acylsphingosine amidohydrolase (alkaline ceramidase) 3;alkCDase 1;alkaline CDase 1;acylsphingosine deacylase 3;N-acylsphingosine amidohydrolase 3;N-acylsphingosine amidohydrolase (alkaline ceramidase) 3;ASAH3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- zebrafish
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ACER1 involved in several pathways and played different roles in them. We selected most pathways ACER1 participated on our site, such as Metabolic pathways,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid de novo biosynthesis | PPM1LB,GDF1,PPM1L,CERS5,SGMS2,OSBP,CERS3B,CERS4A,FA2H,VAPB |
| Metabolism | SULT2ST2,ACOT6,NDUFAF2,GLTP,IDO2,TYMP,ACSM1,CYP2A13,MED16,SLC25A2 |
| sphingosine and sphingosine-1-phosphate metabolism | PTGR1 |
| Sphingolipid metabolism | GAL3ST1A,SUMF2,DEGS2,GLTPA,GDF1,SGPL1,SGMS2,PPM1LB,GALCA,SPTLC2 |
| Metabolism of lipids and lipoproteins | THEM5,AKR1C2,CERS3B,ACOT6,FABP11A,MED29,PHOSPHO1,CERS5,NEU4,GDF1 |
| Sphingolipid signaling pathway | PPP2R5A,PRKCA,SGPP1,PLD1,PRKCZ,PIK3R2,PPP2R5D,PLCB4,PPP2R2D,PIK3R1 |
| Metabolic pathways | BTD,CBSA,GNPDA2,PNLIP,GALNT14,ALG14,GAL3ST1,ASPA,ODC1,POLR2G |
Protein Function
ACER1 has several biochemical functions, for example, ceramidase activity,dihydroceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACER1 itself. We selected most functions ACER1 had, and list some proteins which have the same functions with ACER1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ceramidase activity | ASAH1B,ASAH2,ASAH1 |
Interacting Protein
ACER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACER1.
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