ABO
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Official Full Name
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -
Overview
This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. -
Synonyms
ABO;ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase;transferase B, alpha 1-3-galactosyltransferase);histo-blood group ABO system transferase;A3GALNT;A3GALT1;ABO glycosyltransferase;histo-blood group A transferase;histo-
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Mus musculus
- E.coli
- CHO
- Human
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- E. coli
- E.coli expression system
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- His&GFP
- Fc
- N-His
Involved Pathway
ABO involved in several pathways and played different roles in them. We selected most pathways ABO participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PIP5K1C,GALK1,GLB1,OCRL,PTGS1,TWISTNB,PGAM2,SDHC,CYP2P10,AMY2A2 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | GCNT2,FUT5,ST3GAL4,FUT9,FUT1,ST3GAL6,B3GNT2B,FUT9A,B4GALT2,GGTA1 |
Protein Function
ABO has several biochemical functions, for example, fucosylgalactoside 3-alpha-galactosyltransferase activity,glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABO itself. We selected most functions ABO had, and list some proteins which have the same functions with ABO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | HDAC7,MDP1,ACVR2AA,BHLHE22,ABLIM1A,ZFP276,LOXL2B,RNF207,ZNF621,LNX2A |
Interacting Protein
ABO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABO here. Most of them are supplied by our site. Hope this information will be useful for your research of ABO.
Resources
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References
- Ganji, F; Abroun, S; et al. Differentiation Potential of O Bombay Human-Induced Pluripotent Stem Cells and Human Embryonic Stem Cells into Fetal Erythroid-Like Cells. CELL JOURNAL 16:426-439(2015).
- Noiphung, J; Talalak, K; et al. A novel paper-based assay for the simultaneous determination of Rh typing and forward and reverse ABO blood groups. BIOSENSORS & BIOELECTRONICS 67:485-489(2015).
