AAK1
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Official Full Name
AP2 associated kinase 1 -
Overview
AAK1 is a serine/threonine kinase that is thought to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the μ2 subunit. There is strong evidence that this protein is the endogenous mu 2 kina -
Synonyms
AAK1;AP2 associated kinase 1;AP2-associated protein kinase 1;DKFZp686K16132;KIAA1048;adaptor-associated kinase 1;FLJ23712;FLJ25931;FLJ31060;FLJ42882;FLJ45252;MGC138170;MGC164568;MGC164570;DKFZp686F03202
Recombinant Proteins
- Human
- Mouse
- Rat
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- Sf9 Cells
- His
- GST
- Non
- GST&His
- Avi&Fc&His
Involved Pathway
AAK1 involved in several pathways and played different roles in them. We selected most pathways AAK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AAK1 has several biochemical functions, for example, AP-2 adaptor complex binding,ATP binding,Notch binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AAK1 itself. We selected most functions AAK1 had, and list some proteins which have the same functions with AAK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | 2610109H07Rik,PITPNM3,MAK,FHL5,ZNF187,TLE2,MTERFD2,DNM3,ANXA1,HADHB |
| Notch binding | ADAM17,DNER,NOV,DTX1,C8orf4,DLL4,NCOR2,JAG1A,CHAC1,HIF1AN |
| protein serine/threonine kinase activity | TSSK1,RPS6KA1,FAM20C,CHEK2,CSNK1A1,ALPK2,BCR,PLK3,GRK1A,PAK2A |
| ATP binding | PIM1,SKIV2L2,TARS2,PAK2B,PIM2,PDPK1A,DMC1,GRK1A,PIP5K1C,BMX |
| AP-2 adaptor complex binding | LDLRAP1,TBC1D5,ARRB1,FCHO1,OTOF |
Interacting Protein
AAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AAK1.
AP2M1;ATP13A2;czc8004;linkable sunitinib analogue;bosutinib;imatinib;dasatinib;midostaurin;AP2A1;GABARAPL2;AP2B1
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References
- Zhao, PQ; Deng, Y; et al. Insulin-like growth factor 1 promotes the proliferation and adipogenesis of orbital adipose-derived stromal cells in thyroid-associated ophthalmopathy. EXPERIMENTAL EYE RESEARCH 107:65-73(2013).
- Lee, J; Lee, J; et al. Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2. JOURNAL OF BIOLOGICAL CHEMISTRY 285:32647-32656(2010).
