YES1
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Official Full Name
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 -
Overview
The cellular oncogene c-Yes and its viral homologue v-Yes (the transforming gene of Yamaguchi 73 and Esh avian sarcoma viruses) encode a 60 kDa, cytoplasmic, membrane-associated, protein-tyrosine kinase. Yes belongs to the Src kinase family and is ubiquit -
Synonyms
YES1;v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1;tyrosine-protein kinase Yes;c yes;HsT441;Yes;proto-oncogene c-Yes;cellular yes-1 protein;Yamaguchi sarcoma oncogene;proto-oncogene tyrosine-protein kinase YES;c-yes;P61-YES
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Sf9 Cells
- Mammalian Cells
- Insect Cells
- HEK293
- Sf21 Cells
- His
- GST
- Non
- His&GST
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
YES1 involved in several pathways and played different roles in them. We selected most pathways YES1 participated on our site, such as Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with YES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | FGFR1,NLK,CDC42L2,WASF2,IGF1RB,EGFR,RHOAD,SMAD3A,TGFBR1B,FYNB |
| Tight junction | F11R,PARD6GA,HCLS1,MAGI2,CLDN2,MYHC4,MYH9,CLDN15LA,PARD3,CLDN15LB |
Protein Function
YES1 has several biochemical functions, for example, ATP binding,enzyme binding,epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YES1 itself. We selected most functions YES1 had, and list some proteins which have the same functions with YES1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| non-membrane spanning protein tyrosine kinase activity | SYK,JAK2B,BTK,STK16,TYK2,JAK1,JAK3,FYNA,PTK2AB,FES |
| protein binding | FAM195B,COPS3,NUB1,LIN9,PRKAB1,NCF1,MYO6,TERF1,HRK,CLTC |
| receptor binding | PRDX5,EDA,TNFSF4,HACL1,PDGFRB,HSD17B4,LYN,CHRNA10,AKAP9,AMH |
| ion channel binding | KCNQ1,CAMK2D,SCN5A,LRRK2,PPP1R9B,PIRT,SCN3B,CALM1,CALM3,KCNIP1 |
| epidermal growth factor receptor binding | CBLC,EGF,HBEGF,EPGN,VAV3,MS4A1,SHC1,TGFA,FER,HBEGFB |
| enzyme binding | SLC18A1,MSH3,NFKBIA,MLL5,SIRT3,ARRB2,MAPK8,TSPAN14,NPC2,HSPA6 |
| protein tyrosine kinase activity | EPHB4A,IGF1RB,EPHB2,ERBB2,INSRA,ERBB4,MAP2K3,Aatk,EPHA7,NTRK3A |
| ATP binding | YRK,HARS2,STK11,PNKP,MAPK13,PAK6,UBA7,ATP1A3B,CAMKK1A,RUVBL1 |
Interacting Protein
YES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YES1.
OLIG1;PTK2;SOCS3;EGFR;FXR2;TRAF2;C1orf94
Resources
Research Area
Intracellular Kinases in the Akt PathwaySrc Kinases
Negative Regulators of the Jak/STAT Pathway
Oncoprotein-Signal Transducers
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References
