YBX1
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Official Full Name
Y box binding protein 1 -
Overview
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.<br/>The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. -
Synonyms
YBX1;Y box binding protein 1;YB1;BP-8;CSDB;DBPB;YB-1;CSDA2;NSEP1;NSEP-1;MDR-NF1;nuclease-sensitive element-binding protein 1;CBF-A;EFI-A;DNA-binding protein B;Y-box-binding protein 1;Y-box transcription factor;enhancer factor I subunit A;nuclease sensitive element binding protein 1;CCAAT-binding transcription factor I subunit A;major histocompatibility complex, class II, Y box-binding protein I
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
YBX1 involved in several pathways and played different roles in them. We selected most pathways YBX1 participated on our site, such as BDNF signaling pathway,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with YBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BDNF signaling pathway | LINGO1,EIF4EBP1,KCNN2,CDH2,SIRPA,SYN1,CDK5,CSNK2A1,DOK5,GRIP1 |
| Signaling events mediated by PTP1B | NOX4,CSN2,DOK1 |
| mRNA Splicing - Minor Pathway | SNRNP35,PRPF8,SNRNP48,SF3B4,PDCD7,SNRNP25,ZMAT5,RNPC3,ZCRB1,SF3B2 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPH2,U2AF2,PDCD7,HNRNPL2,PCBP2,SUGP1,PAPOLA,SNRNP35,METTL3,THOC4 |
| SIDS Susceptibility Pathways | POU3F2,FOXM1,CTCF,CHRFAM7A,SP3,KCNJ8,GATA2,PHOX2A,MECP2,KCNH2 |
| mRNA Splicing - Major Pathway | HNRNPR,HNRNPA0B,HNRNPA0A,HNRNPA0L,HNRNPA2B1,PTBP1A,SF3A3,RBM5,SF3A1,HNRNPH2 |
| mRNA Splicing | TTC6,PTBP1B,PCBP2,ZCRB1,SFRS3A,HNRNPL2,HNRNPR,SNRNP25,SUGP1,DNAJC8 |
| Gene Expression | ZNF205,ZNF157,LAMTOR1,MED23,RORAA,ZNF582,TET3,ZNF792,NR2F6B,ZNF493 |
Protein Function
YBX1 has several biochemical functions, for example, DNA binding,GTPase binding,RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YBX1 itself. We selected most functions YBX1 had, and list some proteins which have the same functions with YBX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | SP1,RAD51AP1,XRCC5,CTNNB1,SAFB,DDX11,MTERFD1,TEF,NKX2-8,PYDC3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ETV6,NRF1,HNRNPK,MEOX1,CAMTA1,ELK3,MIXL1,HMGA2,NR4A3,ETV2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF713,AEBP2,ZNF217,GMEB2,NPAS4,HOXA2,MYOD1,SKIL,NDN,ZNF148 |
| single-stranded DNA binding | NABP1,LONP1,TTC6,MLH3,POLR2G,RAD23B,HNRPDL,MCM6,TDP2B,RAD51AP1 |
| poly(A) RNA binding | CSDE1,ZC3H10,PFN1,HIST1H4H,TRMT6,RPS15,NXF3,NOL10,RPL18A,FKBP4 |
| chromatin binding | SIRT7,APBB1,ARID5A,RNF2,MED1,ENY2,SMAD6,CCNT1,TOX4,PRKCBP1L |
| DNA binding | TERT,TERF1,FOXA,SMARCC1,HOXC8A,HOXC12,FOXO1A,FOXS1,IFT57,MEOX2B |
| GTPase binding | MARCH5,STOML2,GNB3,SH3GL1,RASA1,VPS41,AIMP1,GM5506,ENO1,LCP1 |
| RNA binding | SF1,IMPDH1,PTBP1A,KHDC1B,FUS,UBR5,PATL2,RPL8,CELF1,AGFG1A |
Interacting Protein
YBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YBX1.
SYNCRIP;C1QBP;HNRNPR;DHX9
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References
- Blackwell, E; Ceman, S; et al. A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein. JOURNAL OF CELL SCIENCE 124:3060-3065(2011).
