XRN1
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Official Full Name
5"-3" exoribonuclease 1 -
Overview
SEP1 has been reported by group of Takahashi, as a gene enhancing its expression by stimulation by a neurotrophic factor, GDNF. Though SEP1 is found in every organ, it is located at neurite of neuroblastoma cells of which differentiation is induced by GDNF, and SEP1 expression has been confirmed in many of neurons in an organism. That indicates a possibility that SEP1 relates to neural functions. -
Synonyms
XRN1;5"-3" exoribonuclease 1;SEP1;Strand-exchange protein 1 homolog;FLJ41903;DKFZp434P0721;DKFZp686B22225;DKFZp686F19113;OTTHUMP00000214507;OTTHUMP00000214577;OTTHUMP00000214578;EC 3.1.11
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XRN1-102H | Recombinant Human XRN1, His-tagged | E.coli | Human | His | ||
| XRN1-101H | Recombinant Human XRN1, GST-tagged | Wheat Germ | Human | GST |
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| XRN1-11265Z | Recombinant Zebrafish XRN1 | Mammalian Cell | Zebrafish | His |
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| Xrn1-7912R | Recombinant Rat Xrn1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Phe1567~Glu1723 |
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| XRN1-1940HCL | Recombinant Human XRN1 cell lysate | Human | Non |
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| XRN1-552HF | Recombinant Full Length Human XRN1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 459 amino acids |
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Involved Pathway
XRN1 involved in several pathways and played different roles in them. We selected most pathways XRN1 participated on our site, such as Ribosome biogenesis in eukaryotes,RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | CNOT7,CNOT10,PABPC1,PFKM,LSM4,EXOSC3,EXOSC5,RQCD1,PFKL,CNOT2 |
| Ribosome biogenesis in eukaryotes | RAN,EMG1,cka1,IMP4,REX1,LSG1,PWP2H,REXO1,FBL,RBM28 |
Protein Function
XRN1 has several biochemical functions, for example, DNA binding,exonuclease activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRN1 itself. We selected most functions XRN1 had, and list some proteins which have the same functions with XRN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ANO9A,ELF2A,RHOXF1,NKX3.2,ZNF512,MBD1,ZBTB22,ZFP64,HOXB8A,NR1D2A |
| protein binding | TRAPPC4,IL18,NOS1,FAM127A,KRTAP13-3,RTN4A,RNF220,FAM65B,ATXN2,RYBP |
| poly(A) RNA binding | MRPS15,HIST1H1C,SND1,FAM120A,LUZP4,PHF5A,STRBP,SRSF12,KIAA1429,EIF1AX |
| exonuclease activity | AEN,MEIOB,WRN,CNOT6L,LOC81691,REXO4,EXO5,REX1,ISG20,DOM3Z |
Interacting Protein
XRN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRN1.
UPF1;yp016_human;AP1G2;STAM2;LDHA;ALDOA;HNRNPA1;BAG6;CCT5;PABPC4;CHD4;flgE;napF;WAPAL;mnaA;tcaC1;VWA5B2;SPATA20;SMARCD2
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References
- Wollschlaeger, C; Trevijano-Contador, N; et al. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: Implications for virulence and mating. FUNGAL GENETICS AND BIOLOGY 73:20-28(2014).
- Haralambieva, IH; Oberg, AL; et al. High-Dimensional Gene Expression Profiling Studies in High and Low Responders to Primary Smallpox Vaccination. JOURNAL OF INFECTIOUS DISEASES 206:1512-1520(2012).
