XRCC6
-
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 6 -
Overview
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008] -
Synonyms
XRCC6;X-ray repair complementing defective repair in Chinese hamster cells 6;ML8;KU70;TLAA;CTC75;CTCBF;G22P1;X-ray repair cross-complementing protein 6;5-dRP lyase Ku70;Ku autoantigen, 70kDa;DNA repair protein XRCC6;Ku autoantigen p70 subunit;70 kDa subunit of Ku antigen;thyroid-lupus autoantigen p70;lupus Ku autoantigen protein p70;5-deoxyribose-5-phosphate lyase Ku70;CTC box binding factor 75 kDa subunit;CTC box-binding factor 75 kDa subunit;thyroid autoantigen 70kD (Ku antigen);ATP-dependent DNA helicase 2 subunit 1;thyroid autoantigen 70kDa (Ku antigen);ATP-dependent DNA helicase II 70 kDa subunit;ATP-dependent DNA helicase II, 70 kDa subunit
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Rat
- Chicken
- Mammalian Cells
- E.coli
- Insect Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Flag
- Flag&Strep&His
- Myc&DDK
Involved Pathway
XRCC6 involved in several pathways and played different roles in them. We selected most pathways XRCC6 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-homologous end-joining | DCLRE1C,XRCC5,NHEJ1,FEN1,POLM,MRE11A,DNTT,PRKDC,LIG4,XRCC4 |
Protein Function
XRCC6 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity,ATP binding,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC6 itself. We selected most functions XRCC6 had, and list some proteins which have the same functions with XRCC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSNK2A2A,ABCD3A,ACVR1,DCAKD,PFKMA,SMYHC2,NEK3,ADCY6,CKM,PEO1 |
| double-stranded DNA binding | KIN,DDX58,RAD51C,MRE11A,CSDA,SP8B,KLF6,TP73,RAD51,DMC1 |
| DNA binding | ZNF334,ZKSCAN17,SOX6,POLR3C,NFE2L2,ZNF286A,ERCC6L,PPARA,GSX2,HOXD10A |
| poly(A) RNA binding | PSMD4,HIST1H4E,SRP54B,REXO4,HNRNPA2B1,ELAC2,NCOA5,LSM6,SRSF7,TFAM |
| damaged DNA binding | ERCC1,HMGB2,POLK,RAD23B,RAD23A,TDG,APTX,H2AFX,FEN1,DCLRE1A |
| contributes_to double-stranded telomeric DNA binding | XRCC5 |
| 5-deoxyribose-5-phosphate lyase activity | HMGA1,HMGA2,HMGA1-RS1 |
| ATP-dependent DNA helicase activity | ERCC3,RUVBL2,DDX3X,FBXO18,DDX11,BLM,CHD4,CHD2,CHST13,XRCC5 |
| transcription regulatory region DNA binding | TCF7L1B,CREB3L2,PPARG,WT1,HHEX,HNF4A,HDAC1,ASH2L,PHB,Arid4b |
Interacting Protein
XRCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC6.
XRCC5;PRKDC;WRN
Resources
Related Services
Related Products
References
