XDH
-
Official Full Name
xanthine dehydrogenase -
Overview
Xanthine oxidase (XO (sometimes 'XAO'), a form of xanthine oxidoreductase that generates reactive oxygen species) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. This enzyme plays an important role in the catabolism of purines in some species. -
Synonyms
XDH;xanthine dehydrogenase/oxidase;XO;Xanthine Oxidase
Recombinant Proteins
- Mouse
- Bovine
- Human
- Rat
- Chicken
- E.coli
- HEK293T
- HEK293
- Mammalian Cell
- Wheat Germ (in vitro)
- Mamanlian cells
- His&T7
- His&GST
- Myc&DDK
- His
- Non
- His&Fc&Avi
- GST
- Flag
Involved Pathway
XDH involved in several pathways and played different roles in them. We selected most pathways XDH participated on our site, such as Purine metabolism,Caffeine metabolism,Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with XDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | CES1D,UPP2,IMPDH1,IMPDH1B,UCK2A,UCK2B,Ces2c,CYP2A6,UGT5G1,UGT1A4 |
| Purine metabolism | PPAT,AMPD1,POLD2,NUDT5,ENTPD2A.1,PGM2,POLR3D,CECR1A,PRIM2,PNP5B |
| Metabolic pathways | CYP2B6,NANSA,NDUFB1,GAD1B,NT5C1B-RDH14,ACSM1,PLCB2,POLR3H,P4HA1A,PMVK |
| Caffeine metabolism | PNAT10,UOX,PNAT3,CYP1A2,Nat3,NAT2,NAT,CYP2A6,NAT1 |
| Peroxisome | ACSL1A,PHYH,NUDT12,EPHX2,NUDT19,CRATB,PEX2,PEX7,DECR2,PRDX5 |
Protein Function
XDH has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,electron carrier activity,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XDH itself. We selected most functions XDH had, and list some proteins which have the same functions with XDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PEX11B,XBP1,MAP3K10,BMPR1A,DMRTC1B,MCL1,MYH9,CADM4,TWIST1,CHEK2 |
| xanthine dehydrogenase activity | AOX1 |
| flavin adenine dinucleotide binding | D2HGDH,LDHD,DUS3L,AIFM3,GCDHB,FMO1,TXNRD2,NOS1,AOX1,ACAD9 |
| 2 iron, 2 sulfur cluster binding | NDUFS1,AOX1,AIFM3,CISD3,ISCA1,ISCU,ISCUB,RFESD,CMAH,GLRX5 |
| iron ion binding | CYP1D1,CYP8B1,SCD,CYP2J2,CYP46A1.1,CYP2B6,CYP21A1,ALOX5A,CYP2AA12,EGLN1B |
| molybdopterin cofactor binding | SUOX,AOX1,MARC1,MOSC2,MARC2 |
| oxidoreductase activity, acting on CH-OH group of donors | GULO,AOX1,AGPS,AOX4,AOX3,DHCR24,AOX3L1 |
| electron carrier activity | SRD5A1,FDX1L,ACOXL,SDHC,COX7A3,ACOX3,GLRX3,PTGESL,FDX1B,DHRS3 |
Interacting Protein
XDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XDH here. Most of them are supplied by our site. Hope this information will be useful for your research of XDH.
Xpo1;MYC
Resources
Related Services
Related Products
References
- Dkhil, MA; Al-Quraishy, S; et al. Eimeria coecicola: Spleen response of Oryctolagus cuniculus. EXPERIMENTAL PARASITOLOGY 133:137-143(2013).
- Xin, Y; Yang, HL; et al. Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp.. PROCESS BIOCHEMISTRY 47:1539-1544(2012).
