WWOX
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Official Full Name
WW domain containing oxidoreductase -
Overview
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
WWOX;WW domain containing oxidoreductase;FOR;WOX1;FRA16D;SCAR12;HHCMA56;PRO0128;SDR41C1;D16S432E;WW domain-containing oxidoreductase;WW domain-containing protein WWOX;fragile site FRA16D oxidoreductase;short chain dehydrogenase/reductase family 41C, member 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
WWOX involved in several pathways and played different roles in them. We selected most pathways WWOX participated on our site, such as ErbB4 signaling events,Nuclear signaling by ERBB4,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by ERBB4 | CSN2,GHRB,CSHL1,PRLRB |
| Signal Transduction | RHOT1B,GPRC6A,FSTL3,SKIA,SOX13,USP4,WIPF2,RAB6A,PTHLH,SOX4B |
| ErbB4 signaling events | WWP1,YAP1,CBFA2T3 |
| Nuclear signaling by ERBB4 | CSH1,YAP1,GHRB,CSN2,CSHL1,PRLRB |
Protein Function
WWOX has several biochemical functions, for example, contributes_to RNA polymerase II transcription coactivator activity,coenzyme binding,cofactor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WWOX itself. We selected most functions WWOX had, and list some proteins which have the same functions with WWOX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA polymerase II transcription coactivator activity | HIPK2 |
| cofactor binding | PAH,LMO2,C3,TYMS,ASNS,HACL1,ME3,HIF1AN,PGAM2,DAO |
| coenzyme binding | TSTA3,TDH,HMGCRA,NDUFA9,HMGCRB,NDUFA9A,ATAT1,QDPRB1,GCLC,GCH1 |
| protein binding | DNMT3L,THEMIS,RFPL3,AMELX,COMP,CCL3,RHOBTB3,SNRPD2,ERCC6L,PTPN3 |
| enzyme binding | JUN,RAD9,TOP2B,HIF1A,SLC12A3,TBP,HIST1H2AL,NPM2,CRB2,HINFP |
| oxidoreductase activity | TXNRD3,KIAA1191,DIO3,NOS2A,TDO2B,SNCA,HIBADHA,RDH1,CYP46A1.4,DHRS11B |
| protein dimerization activity | DAO,LYL1,PIP,TAL2,HER15.1,SREBF1,NHLH1,DBI,GARS,ID4 |
Interacting Protein
WWOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWOX here. Most of them are supplied by our site. Hope this information will be useful for your research of WWOX.
LITAF;TP73;WBP1;TP73
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References
- Woodfield, GW; Chen, YZ; et al. Identification of Primary Gene Targets of TFAP2C in Hormone Responsive Breast Carcinoma Cells. GENES CHROMOSOMES & CANCER 49:948-962(2010).
- Jamshidiha, M; Habibollahi, P; et al. Primary WWOX phosphorylation and JNK activation during etoposide induces cytotoxicity in HEK293 cells. DARU-JOURNAL OF FACULTY OF PHARMACY 18:141-145(2010).
