WNT1
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Official Full Name
wingless-type MMTV integration site family, member 1 -
Overview
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] -
Synonyms
WNT1;wingless-type MMTV integration site family, member 1;INT1;OI15;BMND16;proto-oncogene Wnt-1;proto-oncogene Int-1 homolog;wingless-type MMTV integration site family, member 1 (oncogene INT1)
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Mammalian Cell
- Human Cell
- E.coli
- HEK293
- CHO Cell
- His
- StrepII
- Non
- His&Fc&Avi
- His&GST
- N-His-GST&C-Myc
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WNT1-18563M | Recombinant Mouse WNT1 Protein | Mammalian Cell | Mouse | His |
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| WNT1-204H | Recombinant Human WNT1, StrepII-tagged | Human Cell | Human | StrepII | 28-370, 343 a.a. |
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| WNT1-560H | Recombinant Human WNT1 | E.coli | Human | Non |
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| WNT1-7923Z | Recombinant Zebrafish WNT1 | Mammalian Cell | Zebrafish | His |
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| WNT1-304HCL | Recombinant Human WNT1 293 Cell Lysate | HEK293 | Human | Non |
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| Wnt1-001M | Active Recombinant Mouse Wnt-1/sFRP-1 Complex Protein | CHO Cell | Mouse | Non |
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| WNT1-10190M | Recombinant Mouse WNT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| WNT1-10190M-B | Recombinant Mouse WNT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| WNT1-110H | Recombinant Human WNT1 Protein | E.coli | Human |
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| WNT1-3402R | Recombinant Rat WNT1 protein, His-GST-tagged | E.coli | Rat | His&GST | Ala28~Leu370 |
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| WNT1-5621H | Recombinant Human WNT1 protein, His-GST&Myc-tagged | E.coli | Human | N-His-GST&C-Myc | 142-288aa |
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| WNT1-581H | Recombinant Human WNT1 Protein, His&GST-tagged | E.coli | Human | His&GST | Ala28-Leu370 |
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| Wnt1-5875M | Recombinant Mouse Wnt1 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 28-370aa |
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Involved Pathway
WNT1 involved in several pathways and played different roles in them. We selected most pathways WNT1 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | ITGB3,TGFB2,SMAD2,FGFR1,DDX5,ITGAV,PIK3CD,VAV2,PLAU,PRKACB |
| Basal cell carcinoma | APC,WNT7A,FZD5,FZD9,PTCH2,PTCH1,GLI2,WNT6,WNT3,BMP2 |
| Melanogenesis | HRAS,FZD7,MITFA,GNA11A,EDNRB2,ADCY1B,WNT9A,WNT3A,LEF1,CALM2A |
| Hippo signaling pathway | FGF1,APC2,LATS1,SOX2,JUB,CRB1,WNT9A,ACTG1,LLGL1,BMPR1A |
| Signaling pathways regulating pluripotency of stem cells | PCGF5,SMAD2,PIK3CA,BMP2,ZFHX3,JARID2,WNT10B,WNT8A,ACVR1B,MAP2K2 |
| Wnt signaling pathway | CTBP2A,PPP3CB,RHOA,SIAH1A,FZD7A,CAMK2A,PPP3CCB,NFATC4,VANGL1,CAMK2D1 |
| Hedgehog signaling pathway | CSNK1G2A,WNT8A,BTRC,PRKACAB,HHIP,PRKACBB,CSNK1G3,WNT7A,WNT5A,FBXW11 |
| HTLV-I infection | LTA,IL15,FOS,IL2RG,PDGFB,PIK3R1,POLB,TGFB1,PRKACG,MYB |
| Pathways in cancer | VHL,GNG2,MMP9,TRAF2,PIK3R5,IKBKB,STAT3,KRAS,NKX3,STAT5B |
Protein Function
WNT1 has several biochemical functions, for example, cytokine activity,frizzled binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT1 itself. We selected most functions WNT1 had, and list some proteins which have the same functions with WNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | PRKCI,RUNX2,TRIM11,WNT3,HIST1H4I,AKAP1,NCK1,MLF1,ST13,HIST1H4A |
| cytokine activity | Ifnz,IFNG1-2,AIMP1,Il1f9,IL11,CCL4,IFNPHI4,BMP1,IFNG1-1,CSF2 |
| transcription regulatory region DNA binding | TAL1,NKX3,WT1,TRP63,NR1D1,ATF6B,NFKB1,XRCC5,BCL11B,Arid4b |
| frizzled binding | FZD1,WNT7A,WNT4,DVL1,ROR2,WNT2BB,WNT2,MYOC,WNT3A,FZD7 |
| receptor agonist activity | WNT3,WNT4,WNT3A,SFRP2,CXCL13,WNT10B,NODAL,WNT2,GREM1,WNT5A |
Interacting Protein
WNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT1.
WNT1 Related Signal Pathway
Resources
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References
- Jing, D; Cai, J; et al. Pulsed Electromagnetic Fields Partially Preserve Bone Mass, Microarchitecture, and Strength by Promoting Bone Formation in Hindlimb-Suspended Rats. JOURNAL OF BONE AND MINERAL RESEARCH 29:2250-2261(2014).
- Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).
