VPS4A
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Official Full Name
vacuolar protein sorting 4 homolog A (S. cerevisiae) -
Overview
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. -
Synonyms
VPS4A;vacuolar protein sorting 4 homolog A (S. cerevisiae);vacuolar protein sorting 4A (yeast homolog) , vacuolar protein sorting 4A (yeast);vacuolar protein sorting-associated protein 4A;FLJ22197;SKD1;SKD1A;SKD2;VPS4;VPS4 1;hVPS4;SKD1 homolog;SKD1-homolog;Vacuolar protein sorting 4 homolog A;vacuolar protein sorting 4A (yeast);vacuolar protein sorting factor 4A;Vacuolar protein sorting-associating protein 4A;vacuolar sorting protein 4;VPS4-1
Recombinant Proteins
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- GST
- Myc&DDK
- His&Myc
Involved Pathway
VPS4A involved in several pathways and played different roles in them. We selected most pathways VPS4A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PSD,ARF6A,VPS37A,PARD6GB,ARR3A,VPS37D,MDM2,HGS,ARF6B,LDLRAP1B |
Protein Function
VPS4A has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS4A itself. We selected most functions VPS4A had, and list some proteins which have the same functions with VPS4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MCM5,TTLL13,MST1R,ACSM4,NAIP1,AK7,UBA6,NLRC5,CERK,CAMKVB |
| protein domain specific binding | CNTLN,ZFP521,EFS,STAMBP,UNC13A,Akap2,EZR,IPCEF1,KCNN2,ZNF521 |
| ATPase activity | HAND2,BLM,ABCB1A,PMS2,DNAHC8,ABCG2D,MLH3,ABCE1,ATP13A3,HSPA1B |
| protein binding | TRAPPC4,XIAP,MED21,ARL2BP,CXCL14,RAB6A,SETD7,MYO5B,VPS53,ERGIC1 |
| protein C-terminus binding | PEX10,DLG3,KCNIP3,ATF4,NEIL1,RAD51,VGLL3,XRCC4,SAE1,MAP3K7 |
| NOT microtubule-severing ATPase activity | VPS4B |
| ATPase activity, coupled | VPS4B,NSF,MYH3,ABCB1A,MYO1E,PEX1,CCT8,HSPA1A,HSPA8,HSPA1B |
Interacting Protein
VPS4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS4A here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS4A.
NFKB1;BABAM1;pi3p;CFTR;Smo;LRRK2;CENPQ;NABP2;TMEM248;TUBA1A;PDCD6IP
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