VEGFB
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Official Full Name
vascular endothelial growth factor B -
Overview
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. -
Synonyms
VEGFB;vascular endothelial growth factor B;VEGF-related factor;Vrf;VEGF-B
Recombinant Proteins
- Human
- Mouse
- Cattle
- Dog
- Rat
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- Human
- Yeast
- Non
- His
- Fc
- StrepII
- His&T7
- His&Strep
- His&Fc&Avi
- His&GST&Myc
- Myc&DDK
- His&SUMO
Involved Pathway
VEGFB involved in several pathways and played different roles in them. We selected most pathways VEGFB participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VEGFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | ITGA10,ITGA3B,AKT2,CCND1,ACTB2,PPP1R12C,MYLK3,RAP1AA,MYLK4,RAC1A |
| Pathways in cancer | WNT8A,SOS1,PIK3R1,RAD51,EGLN3,FGF5,RAC2,ROCK1,NCOA4,MTOR |
| Rap signaling pathway | LPAR3,ACTG1,CALML3,ARAP3,CALM1,FGF19,FGF9,ITGA2B,PIK3CB,SIPA1L2 |
| PIK-Akt signaling pathway | LAMC1,NR4A1,MDM2,PPP2R2D,PPP2R1A,RAC1,PDPK1,MTCP1,PPP2R2C,PPP2R2B |
| Ras signaling pathway | PLA2G5,RAPGEF5,PLCG2,LOC608458,GNG7,PDGFRA,INS,RASA3,GNG2,ETS2 |
| Cytokine-cytokine receptor interaction | CXCL12,Ifna11,LOC100033925,HGF,Il23a; Il12b,CCL21B,CRLF2,TNFRSF1A,CXCL8,IFNA14 |
Protein Function
VEGFB has several biochemical functions, for example, chemoattractant activity,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VEGFB itself. We selected most functions VEGFB had, and list some proteins which have the same functions with VEGFB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TENM2,CHRAC1,BNIP3,H2AFY2,Bcl2a1b,PPP2R4,SMAD2,H2AFB3,ATF6,UGT1A7 |
| heparin binding | PF4,FN1,HDGF,PGF,FGF4,LXN,ADAMTS1,NRP2,FGF12,REG4 |
| chemoattractant activity | SCG2,CXCL12,SAA4,PDGFB,CCL15,CXCL12B,BMP4,CCL3,FGF2,FGF7 |
| protein binding | IL17A,IER3,WDYHV1,KAT7,NUP35,ATL1,CYB5R2,EHHADH,KCNRG,GOLGA7 |
| protein homodimerization activity | CADM4,AGXT,DHDPSL,LMLN,SMAD3,HES1,DMRT3,USH1G,MAP3K12,TSC2 |
| growth factor activity | MANF,HDGF,TGFA,Artn,PRL2C2,ANGPTL3,FGF1B,Pdgfa&Pdgfb,GPI1,GDNF |
| vascular endothelial growth factor receptor 1 binding | VEGFA |
Interacting Protein
VEGFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VEGFB here. Most of them are supplied by our site. Hope this information will be useful for your research of VEGFB.
VEGFA;ftsK
Resources
Research Area
VEGF FamilyVascular Endothelial Growth Factors (VEGFs)
Rheumatoid arthritis Therapeutic Targets
Related Services
Related Products
References
- Lee, JE; Kim, C; et al. Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression. MOLECULAR CANCER THERAPEUTICS 14:470-479(2015).
- Vecchione, A; Belletti, B; et al. A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:9845-9850(2013).
