VDAC1
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Official Full Name
voltage-dependent anion channel 1 -
Overview
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] -
Synonyms
VDAC1;voltage-dependent anion channel 1;PORIN;VDAC-1;voltage-dependent anion-selective channel protein 1;porin 31HL;porin 31HM;plasmalemmal porin;outer mitochondrial membrane protein porin 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- Flag
- His&Fc&Avi
Involved Pathway
VDAC1 involved in several pathways and played different roles in them. We selected most pathways VDAC1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | UBB,SLC25A4,NDUFB11,NDUFV3,UQCRQ,NDUFS1,NDUFS3,ATP5D,SLC6A3,VDAC2 |
| Calcium signaling pathway | CALM1A,TNNC1,HTR5A,PTGFR,CD38,AKR1C1,NOS3,PPP3CCA,PRKACBA,Adcy4 |
| Huntingtons disease | NDUFA7,PLCB1,NDUFC2,GPX1,DCTN2,NDUFS5,NDUFA1,NDUFB8,POLR2J2,PLCB3 |
| Influenza A | HLA-DPB1,IL18,TMPRSS4,IFNA5,HSPA1L,EIF2AK4,HLA-DQA2,TRIM25,CCL5,OAS2 |
| HTLV-I infection | PIK3R3,TERT,PIK3CG,HLA-DOA,IL2RG,STAT5B,CRTC2,RRAS2,MYBL1,HLA-DRA |
| cGMP-PKG signaling pathway | PPP3CC,CALM4,MYH7,PLCB3,PPP3R2,ITPR3,PPP3CB,GATA4,INS2,KCNMB3 |
Protein Function
VDAC1 has several biochemical functions, for example, ion channel binding,porin activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC1 itself. We selected most functions VDAC1 had, and list some proteins which have the same functions with VDAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | PCSK2,KHDRBS1,BRK1,STK11,CCNE1,CALY,RRAS,AP2A2,LCK,MYC |
| ion channel binding | RNF207,BAK1,RYR2,SLC8A1,CHERP,FAM115A,PDE4D,PKP2,CIB1,ACTN2 |
| voltage-gated anion channel activity | VDAC2,GPR89,VDAC3,SLC17A3 |
| protein binding | TMEM140,GIT2,COPRS,ZBTB1,DRD4,NR0B1,CCDC112,MX1,VPS37B,CARD11 |
| porin activity | TOMM40,AQP9,VDAC3,TOMM40L,VDAC2 |
| protein kinase binding | PTPN6,NBEA,GCET2,TRIB3,RFFL,SNAP91,DNAJC3,TNNI3,PPP1CB,ZC3HC1 |
Interacting Protein
VDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC1.
ATF2;Bax;BAK1;VCAM1;env;HSPA9;ITPR1;cholesterol;nadh
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References
- Nikiforova, AB; Saris, NEL; et al. External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?. FREE RADICAL BIOLOGY AND MEDICINE 74:74-84(2014).
- Li, L; Yao, YC; et al. Plasminogen Kringle 5 Induces Endothelial Cell Apoptosis by Triggering a Voltage-dependent Anion Channel 1 (VDAC1) Positive Feedback Loop. JOURNAL OF BIOLOGICAL CHEMISTRY 289:-(2014).
