USP5
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Official Full Name
ubiquitin specific peptidase 5 (isopeptidase T) -
Overview
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse;cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A;late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin;monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end;of the chain (Wilkinson et al., 1995 (PubMed 7578059)). -
Synonyms
USP5;ubiquitin specific peptidase 5 (isopeptidase T);ubiquitin specific protease 5 (isopeptidase T);ubiquitin carboxyl-terminal hydrolase 5;IsoT;isopeptidase T;ubiquitin isopeptidase T;ubiquitin thioesterase 5;deubiquitinating enzyme 5;ubiquitin
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Insect Cell
- E.coli
- Mammalian Cell
- E. coli
- HEK293
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
USP5 involved in several pathways and played different roles in them. We selected most pathways USP5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
USP5 has several biochemical functions, for example, cysteine-type endopeptidase activity,omega peptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP5 itself. We selected most functions USP5 had, and list some proteins which have the same functions with USP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIX3,NAV2,F12,PEF1,RND1,KANSL2,SYNJ2,FHL3,ZW10,KRT81 |
| ubiquitin-specific protease activity | USP19,USP44,OTUD6A,OTUD1,USP12A,DUB1,USP6,OTUD4,OTUD5,COPS5 |
| cysteine-type endopeptidase activity | CTSC,USP20,CASP6L2,USP18,CTSL2,CASPBL,USP17L5,CASP1,USP15,ATG4B |
| ubiquitin binding | KCNS1,KIF18A,FAM125A,UBXN2B,TOP2A,HSPB1,OTUB1,USP25,CXCR4,DNAJC2 |
| omega peptidase activity | GGH,USP13,JOSD2,JOSD1,ATXN3L,UCHL1,APEH,ATXN3,UCHL5 |
| zinc ion binding | RAD18,SUV39H2,SETDB1A,CA3,MT2,Shh,ZCCHC3,ZDHHC5,NSMCE2,ZMAT2 |
Interacting Protein
USP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP5.
DAZAP2;TMEM239;TADA3;UBC;ub6l2_human;RAD23B;USP13;TNFRSF10D;PRKAB1;DVL2;RNF11
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