USF1
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Official Full Name
upstream transcription factor 1 -
Overview
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
USF1;upstream transcription factor 1;upstream stimulatory factor 1;bHLHb11;MLTFI;UEF;major late transcription factor 1;class B basic helix-loop-helix protein 11;FCHL;MLTF;FCHL1;HYPLIP1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- Non
- GST
- His
- Myc&DDK
Involved Pathway
USF1 involved in several pathways and played different roles in them. We selected most pathways USF1 participated on our site, such as Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with USF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling mediated by p38-alpha and p38-beta | HBP1,KRT8,GDI1 |
Protein Function
USF1 has several biochemical functions, for example, bHLH transcription factor binding,double-stranded DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USF1 itself. We selected most functions USF1 had, and list some proteins which have the same functions with USF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TFAP2B,HIST1H4B,BCL2L2,SMC4,OSTA,MYO5A,SNX5,HIST1H2BE,HIST1H2AK,IL12B |
| protein binding | DYRK1A,TTK,ACAP1,DNAI2,PRKCI,RNF182,CDC37,EIF4G1,MAGEB18,CUEDC2 |
| protein kinase binding | TBC1D14,MSH2,SPDYB,TPX2,TUBB3,KCNQ3,GRB2,RPTOR,PGAM1,TCF7L2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | BHLHE40,ATF2,PDX1,TFAP4,SOX17,NR5A2,POU4F1,MYOG,HNF4A,TEAD2 |
| bHLH transcription factor binding | USF2,TCF3,IKZF4,PSMD9,TWIST1,LMO2,TCF21,SMAD3,SOX9,TCF3A |
| double-stranded DNA binding | DDX11,LSM14A,IFI16,RAD51B,TRP63,CGGBP1,MTERFD1,SP1,AKAP8,TP73 |
| histone deacetylase binding | SKOR2,BCOR,KAT2B,BRMS1LA,ZNF703,BRMS1L,SOD3,D7ERTD443E,TFAP4,HIST1H1B |
| enzyme binding | BCHE,GSTM7,UGT1A6,YES1,HSPA6,RAC1,PLCE1,PTPLAD1,PUS7,CNTNAP2 |
| protein homodimerization activity | Trl,ARID3A,STK4,NTRK1,CBX5,PDGFC,SLC4A1,GRIK1,TYMS,BOKB |
Interacting Protein
USF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of USF1.
PRKDC;USF2;KAT2B;PARP1;XRCC5;FOSL1
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References
- van Deursen, D; Jansen, H; et al. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. DIABETOLOGIA 51:2078-2087(2008).
- Grassadonia, A; Tinari, N; et al. Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (mac-2BP) protein. ENDOCRINOLOGY 148:3507-3517(2007).
