ULK1
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Official Full Name
unc-51-like kinase 1 -
Overview
Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and cont -
Synonyms
ULK1;unc-51-like kinase 1 (C. elegans);unc 51 (C. elegans) like kinase 1;serine/threonine-protein kinase ULK1;ATG1;ATG1 autophagy related 1 homolog (S. cerevisiae);ATG1A;ATG1 autophagy related 1 homolog;autophagy-related protein 1 homolog;UNC51
Recombinant Proteins
- Human
- Mouse
- Insect cells
- HEK293 Cells
- Sf9 Insect Cell
- Sf9 Insect Cells
- Mammalian Cell
- Free Style 293-F Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Flag
- GST
- N-GST&C-Strep II
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ULK1 involved in several pathways and played different roles in them. We selected most pathways ULK1 participated on our site, such as Regulation of autophagy,mTOR signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PIK3CA,RPS6KB2,RAB2A,PPP2R2C,AKT1,IRS4,G6PC3,IRS2,SCD5,EEF2 |
| Regulation of autophagy | INS,ATG12,ATG4A,ATG13,IFNA1,IFNA8,GABARAPL2,INS1,INS2,ULK2 |
| mTOR signaling pathway | EIF4E2,HIF1A,PIK3R1,CAB39,EIF4EA,INS1,PTEN,PIK3R3A,AKT2,PIK3CG |
Protein Function
ULK1 has several biochemical functions, for example, ATP binding,Rab GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK1 itself. We selected most functions ULK1 had, and list some proteins which have the same functions with ULK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADAMTS3,RASL10B,SIRPB1,KIAA0141,SLN,ATF4,ERH,VEGFA,TAL1,TAC1 |
| protein complex binding | RIPK3,ATP6V0D1,MAPK8IP2,CDK5RAP1,WRN,TMED10,KLHL8,WASF2,ABI1,UGT1A6A |
| ATP binding | EPRS,CTPS1A,CHUK,PRPS2,NLRP3,SLC27A2,CLK2B,PMVK,MCM9,PLK2B |
| Rab GTPase binding | ANKFY1,TMEM127,EVI5L,RABGGTB,EHD1,EXPH5,RPH3AL,RAB11FIP4A,RAB11FIP2,TBC1D30 |
| protein serine/threonine kinase activity | MAPK8B,TBK1,PLK4,SBK1,PLK3,ALPK2,MAP2K7,MAP4K2,LIMK2,PIM1 |
Interacting Protein
ULK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK1.
RB1CC1;GABARAP;GABARAPL2;ATG13;MAP1LC3C;MAP1LC3B;GABARAPL1
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References
- Ribas, VT; Schnepf, B; et al. Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury. BRAIN PATHOLOGY 25:157-170(2015).
- Osaka, M; Ito, D; et al. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1617-1629(2015).
