UBE3A
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Official Full Name
ubiquitin protein ligase E3A -
Overview
UBE3A, also commonly referred to as E6AP (E6 Associated Protein), is an E3 ubiquitin protein ligase and founding member of the HECT (Homologous to the E6 Carboxyl Terminus) family of E3 ligases (1). UBE3A has been shown to be hijacked by the oncogenic E6 -
Synonyms
UBE3A;ubiquitin protein ligase E3A;EPVE6AP, HPVE6A, human papilloma virus E6 associated protein;ubiquitin-protein ligase E3A;ANCR;Angelman syndrome;AS;E6 AP;FLJ26981;CTCL tumor antigen se37-2;E6AP ubiquitin-protein ligase;renal carcinoma antig;E6-AP;HPVE6A;EPVE6AP
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- HEK293T
- Sf9 insect cells
- Insect cells
- Yeast
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- N-His-FLAG
- His&Fc&Avi
- Flag
- Flag&Myc
Involved Pathway
UBE3A involved in several pathways and played different roles in them. We selected most pathways UBE3A participated on our site, such as Ubiquitin mediated proteolysis,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | RCHY1,UBE2D3,RHOBTB1,MGRN1,RFWD2,HUWE1,CUL5,AIRE,UBE2L3B,UBE2Q2 |
| Viral carcinogenesis | HLA-C,KAT2B,HLA-G,HIST1H2BC,IRF3,TRAF5,STAT5A,ACTN4,SCIN,HPN |
Protein Function
UBE3A has several biochemical functions, for example, ligase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE3A itself. We selected most functions UBE3A had, and list some proteins which have the same functions with UBE3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF149,HECW2,ARIH1L,RNF19A,MARCH1,LRSAM1,TOPORS,SIAH1,RNF115,MED7 |
| protein binding | HNRNPR,CD63,MRPL49,DUSP9,HDAC2,IKBKB,CLOCK,ADCY6,CYTH1,POSTN |
| ubiquitin-protein transferase activity | DTX3L,RNF144AA,ZNRF3,FBXO40.1,NHLRC1,RNF10,UBE2E1,MARCH6,MARCH5L,TRIM62 |
| metal ion binding | FYNA,ANKMY2,LOXL2A,FGD2,U2AF1L4,ZNF302,NEURL1B,UNC13C,OMA1,ZNF32 |
| ligase activity | RNF144AA,RAG1,COP1,UBE2CBP,UBR2,MARCH2,SIAH1A,TRIM2,RNF14,TRAF3 |
Interacting Protein
UBE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE3A.
E6;E6;E6;E6;E6;TP53;JADE1
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