UBE2E1

  • Official Full Name

    ubiquitin-conjugating enzyme E2E 1

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

  • Synonyms

    UBE2E1;ubiquitin-conjugating enzyme E2E 1;ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 1 (UBC4/5 homolog, yeast);ubiquitin-conjugating enzyme E2 E1;UbcH6;UB2E1_HUMAN;Ubiquitin carrier protein E1;Ubiquitin-protein ligase E1;OTTHUMP00000161049;OTTHUMP00000161050;OTTHUMP00000208307;OTTHUMP00000208308;OTTHUMP00000208309;ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast);ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Human
  • Mammalian Cell
  • E.coli
  • Insect Cell
  • HEK293
  • His
  • Non
  • His&Strep
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE2E1-17712M Recombinant Mouse UBE2E1 Protein Mammalian Cell Mouse His
UBE2E1-5955Z Recombinant Zebrafish UBE2E1 Mammalian Cell Zebrafish His
UBE2E1-852H Recombinant Human UBE2E1, None tagged E.coli Human Non 2-193 a.a.
UBE2E1-0015H Recombinant Human UBE2E1 Protein (S2-T193), Tag Free Insect Cell Human Non S2-T193
UBE2E1-0016H Recombinant Human UBE2E1 Protein (S2-T193), His/Strep tagged Insect Cell Human His&Strep S2-T193
UBE2E1-174H Recombinant Human UBE2E1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
UBE2E1-254H Recombinant Human UBE2E1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
UBE2E1-310H Recombinant Human UBE2E1 Protein, His-tagged E.coli Human His
UBE2E1-9825M Recombinant Mouse UBE2E1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
UBE2E1-9825M-B Recombinant Mouse UBE2E1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    UBE2E1 involved in several pathways and played different roles in them. We selected most pathways UBE2E1 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum UBE2E2,SSR2,PKZ,HSP90B1,FBXO2,HSPA4L,MAN1A1,SEC63,HSPA5,BAX
    Ubiquitin mediated proteolysis SMURF1,ITCH,FBXW11A,PPIL2,RNF7,MGRN1A,UBA7,CDC27,UBE1Y1,FZR1A

    Protein Function

    UBE2E1 has several biochemical functions, for example, ATP binding,ISG15 transferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E1 itself. We selected most functions UBE2E1 had, and list some proteins which have the same functions with UBE2E1. You can find most of the proteins on our site.

    Function Related Protein
    ISG15 transferase activity HERC5,UBE2E2,UBE2L6
    ATP binding ILK,NLRX1,CDK10,EIF2AK2,ABCA9,SLKA,NLK2,HK1,KIF11,SYK
    protein binding ST8SIA5,ASNA1,PPP1R3C,F2,Pilrb1,FAM167A,RRM2,TRAPPC5,APPL1,BIK
    ubiquitin-protein transferase activity ZFP91,TRIM32,FBXL21,MARCH5L,RNF146,UBE2E2,BIRC5A,ZNF738,UBE2L3,AMFR
    ubiquitin conjugating enzyme activity UBE2V1,UBE2D1,UBE2L3,UBE2N,UBE2D3,UBE2QL1,UBE2T,UBE2R2,UBE2V2,UBE2A

    Interacting Protein

    UBE2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E1.

    ZNRF1;ospG;RNF111;RNF25;RNF5;RNF167;RNF11;PAF1;UBA1;UBE2N

    Resources

    Research Area

    Histone Ubiquitylation
    E2 Ubiquitin/Ubl Conjugating Enzymes

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All UBE2E1 Products

    Required fields are marked with *

    My Review for All UBE2E1 Products

    Required fields are marked with *