UBE2C
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Official Full Name
ubiquitin-conjugating enzyme E2C -
Overview
UbcH10 in conjunction with the anaphase-promoting complex catalyzes the destruction of cyclins A and B and therefore plays an important role in the control of the cell exit from mitosis. -
Synonyms
UBE2C;ubiquitin-conjugating enzyme E2C;ubiquitin-conjugating enzyme E2 C;UBCH10;ubiquitin-protein ligase C;ubiquitin carrier protein C;ubiquitin carrier protein E2-C;cyclin-selective ubiquitin carrier protein;mitotic-specific ubiquitin-conjugating enzyme;dJ447F3.2
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
UBE2C involved in several pathways and played different roles in them. We selected most pathways UBE2C participated on our site, such as APC-Cdc20 mediated degradation of Nek2A,APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Cyclin B, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| APC/C-mediated degradation of cell cycle proteins | PSMD14,CDK2,ANAPC10,PSMD10,PSMA8,AURKB,PSMD9,PSME3,NEK2,PSMD5 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD9,NEK2,PSMA8,ANAPC10,PSMD5,PSMD10,PSMD14,PSME3 |
| APC-Cdc20 mediated degradation of Nek2A | ANAPC10,NEK2 |
| APC/C:Cdc20 mediated degradation of Cyclin B | ANAPC10 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD14,PSMD10,AURKB,PSME3,PSMA8,ANAPC10,PSMD5,PSMD9 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMD14,PSMD5,ANAPC10,NEK2,PSMD10,PSMA8,PSMD9,PSME3 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ANAPC10,PSMD14,PSME3,PSMA8,NEK2,PSMD9,PSMD10,PSMD5 |
| APC/C:Cdc20 mediated degradation of Securin | PSMD9,PSMD5,PSMD10,PSMA8,PSME3,ANAPC10,PSMD14 |
Protein Function
UBE2C has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2C itself. We selected most functions UBE2C had, and list some proteins which have the same functions with UBE2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SFTPD,SAFB2,RIC8A,PPIH,YRDC,KIAA0141,KTI12,RAPGEF6,BAD,HSPD1 |
| ubiquitin-protein transferase activity | RNF130,UBE2O,TRIM23,RNF220,CMTM2A,AMFR,TRIM56,UBE3C,HERC2,RNF144AB |
| ubiquitin protein ligase binding | CCDC50,UBE2G1A,EGR2,DTX1,HSPA1A,VCL,ACVR1B,ASB4,UBE2U,SUMO2 |
| ubiquitin protein ligase activity | HECW2,RNF2,RNF149,PDZRN3,LTN1,UBE2A,TRIM24,TRIM11,CCNC,RNF144B |
| ubiquitin conjugating enzyme activity | UBE2R2,UBE2N,UBE2E2,UBE2A,UBE2J1,UBE2D3,UBE2D2A,UBE2J2,UBE2S,UBE2D1 |
| contributes_to ubiquitin-protein transferase activity | TCEB3B,BTRC,KLHL3,KLHL41B,KEAP1B,KLHDC7B,DTL,CUL3,BCOR,KLHL28 |
| ATP binding | TRPM4,CCT8,MCCC1,KIF12,KIF6,LTK,MAPKAPK2,UBE1Y1,CLK3,KIF3CB |
Interacting Protein
UBE2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2C here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2C.
UBE2V1;ENO2;CXCR1;TNNC1;PCGF3;DTX1;RANBP9;EBNA1BP2;P
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