UBE2B
-
Official Full Name
ubiquitin-conjugating enzyme E2B -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. -
Synonyms
UBE2B;ubiquitin-conjugating enzyme E2B;ubiquitin conjugating enzyme E2B (RAD6 homolog);ubiquitin-conjugating enzyme E2 B;HHR6B;RAD6B;UBC2;E2 protein;RAD6 homolog B;ubiquitin-protein ligase B;ubiquitin carrier protein B;ubiquitin-conjugating enz
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBE2B involved in several pathways and played different roles in them. We selected most pathways UBE2B participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | TRIM32,UBE2D2A,UBE2A,TCEB1B,XIAP,CUL1,SOCS3B,NHLRC1,CUL1B,ANAPC1 |
Protein Function
UBE2B has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2B itself. We selected most functions UBE2B had, and list some proteins which have the same functions with UBE2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF111,TRIM2,LTN1,ANKIB1,MGRN1,RNF180,CDK8,RNF144A,CDC34,RNF7 |
| ubiquitin conjugating enzyme activity | UBE2N,UBE2Q1,UBE2G2,UBE2D2A,UBE2D1,UBE2C,UBE2E3,UBE2O,UBE2Z,UBE2E2 |
| ubiquitin protein ligase binding | ARIH1,HIF1A,UBE2G1,MYOD1,SPG20,YWHAE,AMBRA1,CUL2,GABARAP,IKBKE |
| ubiquitin-protein transferase activity | LMO7,NHLRC1,DTX3L,UBE3A,UBA1,CNOT4,UHRF1,FBXL7,CDC23,TRIM9 |
| protein binding | EPB42,PITX2,ZFYVE9,ANKRD17,SLC1A5,ARGLU1,PSMA2,APOH,BAG4,HSD17B12 |
| ATP binding | FDXACB1,TTBK2,ICK,EPHA3,DDX31,CKMT2B,MYH15,P2RX2,RAF1B,ABCC1 |
Interacting Protein
UBE2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2B here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2B.
RNF20;RAD18;UBC;UNC119;CRMP1;UBR4;UBR3;UBR1;IRF7;MED31;RNF40;PEX2;CDC73
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