UBE2A
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Official Full Name
ubiquitin-conjugating enzyme E2A -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] -
Synonyms
UBE2A;ubiquitin-conjugating enzyme E2A;UBC2;HHR6A;MRXSN;RAD6A;MRXS30;ubiquitin-conjugating enzyme E2 A;RAD6 homolog A;ubiquitin-protein ligase A;ubiquitin carrier protein A
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- His
- Non
- His&Strep
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBE2A involved in several pathways and played different roles in them. We selected most pathways UBE2A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | NEDD4,CDC23,UBE4B,TRAF6,UBE2D4,RFWD2,UBE2E2,RHOBTB1,ANAPC2,NHLRC1 |
Protein Function
UBE2A has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2A itself. We selected most functions UBE2A had, and list some proteins which have the same functions with UBE2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RLIM,UBE2G1,AMFR,TRIM71,UBE2N,TRAF6,RNF126,CMTM2A,UHRF1,MED20 |
| ubiquitin protein ligase binding | PRKAR2B,TRIB1,TRIM37,TRAF1,HDAC6,SLC25A5,TRIB3,CUL3B,CCDC50,GLMN |
| ubiquitin-protein transferase activity | FBXL7,CBL,BARD1,RNF151,FBXO2,MYCBP2,ITCHA,CBLB,HECW2,PDZRN3 |
| ATP binding | NOLC1,MYO5B,DHX8,ATP5A1,ROR1,NLRX1,ACVR2B,RIOK3,FIGN,PLK2 |
| ubiquitin conjugating enzyme activity | UBE2C,UBE2S,UBE2L3,UBE2D2A,UBE2J1,UBE2G1,UBE2B,UBE2Q2,UBE2Z,UBE2V2 |
| protein binding | TNFAIP8L2,RBM17,APAF1,KRT16,TTLL10,SNRPB,EPB41,TPD52,PRKG1,LAIR1 |
Interacting Protein
UBE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2A.
SDCBP;RAD18;RNF20;HAT1;TRIM27;BSG;CRMP1;UBR4;UBR3;UBR1;CMTM2;ETNK2
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References
- Bermejo-Alvarez, P; Rizos, D; et al. Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes. REPRODUCTION 141:801-808(2011).
- Zhang, H; Zhao, WJ; et al. Characterization of a Moniezia expansa ubiquitin-conjugating enzyme E2 cDNA. MOLECULAR BIOLOGY REPORTS 37:1585-1590(2010).
