UBA7
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Official Full Name
ubiquitin-like modifier activating enzyme 7 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. -
Synonyms
UBA7;ubiquitin-like modifier activating enzyme 7;UBE1L, ubiquitin activating enzyme E1 like;ubiquitin-like modifier-activating enzyme 7;D8;UBA1;ubiquitin activating enzyme E1 homolog B (yeast);UBA1B;ubiquitin activating enzyme E1;UBE2;MGC12713;UBA7_HUMAN;Ube 1L;UBE 2;Ubiquitin activating enzyme 2;Ubiquitin activating enzyme E1 homolog;Ubiquitin Activating Enzyme E1 Like;Ubiquitin activating enzyme E1 related protein;Ubiquitin-activating enzyme 7;Ubiquitin-activating enzyme E1 homolog;OTTHUMP00000212701;ubiquitin-activating enzyme-2;UBA7, ubiquitin-activating enzyme E1;UBA1, ubiquitin-activating enzyme E1 homolog B;ubiquitin;UBE1L
Recombinant Proteins
- Human
- Mouse
- Rat
- Insect Cell
- E.coli
- Sf9 Insect Cell
- HEK293
- Mammalian cells
- E. coli
- HEK293T
- His
- His&T7
- GST
- Non
- His&Strep
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBA7 involved in several pathways and played different roles in them. We selected most pathways UBA7 participated on our site, such as Ubiquitin mediated proteolysis,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2QL1,UBE2S,UBE1Y1,SOCS3B,CBLC,ANAPC2,RFWD2,CDC20,AIRE,UBE2IB |
| Parkinsons disease | COX6B2,SNCA,COX7B,ATP5D,NDUFA12,ATP5F1,COX5A,UBE2L3,GNAI3,UQCRB |
Protein Function
UBA7 has several biochemical functions, for example, ATP binding,ISG15 activating enzyme activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA7 itself. We selected most functions UBA7 had, and list some proteins which have the same functions with UBA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin activating enzyme activity | UBA6,ATG7,SAE1,UBE1Y1,UBA1 |
| ATP binding | SBK1,HCK,PPIP5K1,P2RX4,ATP2A1L,DDX19A,KITA,MYO5A,EIF2AK3,MAPK4 |
| ubiquitin-protein transferase activity | UBE2D2,RNF6,NHLRC1,CNOT4,RNF5,TRAF7,WDSUB1,UBE2Q2,RNF213,UBE2K |
| protein binding | DLL4,PLXND1,SRGAP3,CTSL2,LARP4,VDAC1,IRAK1BP1,TRIB3,HDAC1,HNRNPR |
Interacting Protein
UBA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA7.
ISG15;15-deoxy-delta(12,14;SHFM1
Resources
Research Area
Histone UbiquitylationUbiquitin-related Molecules in the Akt Pathway
E1 Ubiquitin/Ubl Activating Enzymes
Related Services
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References
