TNFa

  • Official Full Name

    tumor necrosis factor a (TNF superfamily, member 2)

  • Overview

    Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.

  • Synonyms

    TNFa;TNF;tumor necrosis factor (TNF superfamily, member 2);Cachectin;DIF;OTTHUMP00000029281;OTTHUMP00000037669;TNF-a;TNF-alpha;TNFA;TNFSF2;APC1 protein;TNF superfamily, member 2;TNF, macrophage-derived;TNF, monocyte-derived;Tumor necrosis factor ligand superfamily member 2;tumor necrosis factor alpha

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Atlantic Salmon
  • Pig
  • Guinea Pig
  • Ovine
  • E.coli
  • Yeast
  • HEK293
  • Mammalian Cells
  • His
  • Non
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
TNFA-3314H Recombinant Human TNFA, His-tagged E.coli Human His 1-233aa
mouse Tnfa-2639H Recombinant Mouse Tnfa protein, His-tagged E.coli Mouse His 1-235 aa
tnfa-4382Z Recombinant Zebrafish tnfa Protein Yeast Zebrafish Non 148aa
TNFa-4389A Recombinant Atlantic Salmon TNFa Protein Yeast Atlantic Salmon Non 152aa
TNF-39H Active Recombinant Human TNFa HEK293 Human Non 77-233 a.a.
TNFa-731M Active Recombinant Mouse TNFa Protein, Met-tagged E.coli Mouse Leu 80-Leu 235
TNFA-12120Z Recombinant Zebrafish TNFA Mammalian Cells Zebrafish His
TNFa-24S Recombinant Swine TNF alpha Yeast Pig Non
TNFa-34G Recombinant Guinea Pig TNF alpha Yeast Guinea Pig Non
TNFa-39H Recombinant Human TNF alpha Yeast Human Non
TNFa-70P Recombinant Porcine TNFa E.coli Pig Non
TNFa-89O Recombinant Ovine TNF alpha Yeast Ovine Non
TNFA-1250H Recombinant Human TNFA protein, GST-tagged E.coli Human GST
TNFA-1260H Recombinant Human TNFA protein E.coli Human Non
TNFA-344H Recombinant Human TNFA Protein, Met-tagged, Biotinylated E.coli Human Val77-Leu233
tnfa-3673Z Recombinant Zebrafish tnfa protein, His-tagged E.coli Zebrafish His 59-234aa
TNFA-386H Recombinant Human TNFA protein, GST-tagged E.coli Human GST 77-233 aa
tnfa-439Z Recombinant Zebrafish tnfa Protein, His-tagged E.coli Zebrafish His Ala88-Leu234
TNFa-731MB Recombinant Mouse TNFa Protein, Met-tagged, Biotinylated E.coli Mouse Leu80-Leu235

    Involved Pathway

    TNFa involved in several pathways and played different roles in them. We selected most pathways TNFa participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    TNFa has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TNFa itself. We selected most functions TNFa had, and list some proteins which have the same functions with TNFa. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    TNFa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFa here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFa.

    TNFa Related Signal Pathway

    Resources

    Gene Families

    Cytokines
    Growth Factors

    Research Area

    Cancer Drug Targets
    Neuroinflammation
    Adipocytokines
    Death Receptor–Ligand System
    Cytokines and Growth Factors Secreted by VSMC
    Death Ligands
    Angiogenic Activator
    EMT Induction
    Conventional/Classical Dendritic Cells
    Plasmacytoid Dendritic Cells
    Cytotoxic T Cells (CTLs)
    gamma delta T Cells
    Natural Killer T (NKT) Cells
    Regulatory T Cells (Tregs)
    T Cell Cytokine Signaling
    Tumor Necrosis Factor (TNF)
    Asthma Therapeutic Targets
    Rheumatoid arthritis Therapeutic Targets
    Th1 Cells
    Th22 Cells
    Cytokines in Tumorigenesis
    Angiogenic Activator in Cancer

    References

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