TGIF1
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Official Full Name
TGFB-induced factor homeobox 1 -
Overview
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down modulation of the RXR alpha activities. -
Synonyms
TGIF1;TGFB-induced factor homeobox 1;HPE4, TGFB induced factor (TALE family homeobox) , TGIF;homeobox protein TGIF1;homeobox protein TGIF;5-TG-3 interacting factor;5-TG-3-interacting factor 1;TALE homeobox TG-interacting factor;transforming growt
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TGIF1 involved in several pathways and played different roles in them. We selected most pathways TGIF1 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGIF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | INHBAB,CHD,RPS6KB1B,BAMBI,SMURF2,SMURF1,MYCB,ID1,BAMBIB,AMH |
Protein Function
TGIF1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,co-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGIF1 itself. We selected most functions TGIF1 had, and list some proteins which have the same functions with TGIF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZFP2,FOXD5,ZHX3,PPARAA,ZSCAN20,NKX3-1,MYCLA,RAI1,GATA6,FOXP2 |
| protein binding | LMO1,PSMB9,WRN,MAPK13,PCNA,GP6,FLAD1,CCNE2,TOMM20,TUBG1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | YY1,GZF1,ATF7,NFIL3-2,TFAP2C,SREBF2,IFI16,NR2E1,PROX2,MLXIPL |
| co-SMAD binding | USP9X,SMAD2,SMAD1,SMAD6,SMAD3,CITED1,GATA4,FOXH1,TRIM33 |
| chromatin binding | Ar,ACTL6A,C19orf40,ASCL1,ARX,RELB,NSBP1,POLR2B,TOP1,MKRN1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | RFX3,MYB,FUBP3,IFI203,ZNF562,HLTF,YBX1,EHF,GABPA,ETV6 |
| transcription corepressor activity | ZBTB32,SIRT6,NANOG,DDIT3,TLE2,SIRT1,TFAP2B,EID1,PBXIP1,E2F8 |
Interacting Protein
TGIF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGIF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGIF1.
CTBP2;MDFI;LGALS8;PML
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