Recombinant Human TGIF1 Protein, His-tagged

• Cat.No.: TGIF1-589H
• Product Overview: Recombinant Human TGIF1, transcript variant 4, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 29.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TGIF1 TGFB-induced factor homeobox 1 [ Homo sapiens ]
• Official Symbol: TGIF1
• Synonyms: TGIF1; TGFB-induced factor homeobox 1; HPE4, TGFB induced factor (TALE family homeobox) , TGIF; homeobox protein TGIF1; homeobox protein TGIF; 5-TG-3 interacting factor; 5-TG-3-interacting factor 1; TALE homeobox TG-interacting factor; transforming growth factor-beta-induced factor; HPE4; TGIF; MGC5066; MGC39747
• Gene ID: 7050
• mRNA Refseq: NM_003244
• Protein Refseq: NP_003235
• MIM: 602630
• UniProt ID: Q15583