TCF4
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Official Full Name
transcription factor 4 -
Overview
T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin. -
Synonyms
TCF4;transcription factor 4;bHLHb19;E2 2;ITF2;SEF2 1B;SL3-3 enhancer factor 2;transcription factor 4, isoform D;transcription factor 4, isoform R;immunoglobulin transcription factor 2;class B basic helix-loop-helix protein 19;E2-2;PTHS;SEF2
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cells
- Wheat Germ
- Insect Cells
- E.coli
- DDK
- Myc
- His
- GST
- Non
- Avi
- Fc
- Flag
Involved Pathway
TCF4 involved in several pathways and played different roles in them. We selected most pathways TCF4 participated on our site, such as CDO in myogenesis,Coregulation of Androgen receptor activity,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Coregulation of Androgen receptor activity | TMF1,SNURF,NRIP1,CMTM2,MAK,PATZ1,KDM3A,PIAS3,ZMIZ1,KDM4C |
| CDO in myogenesis | SPAG9,TCF3A,CTNNA1,TCF3B,MEF2AA,MYOD1,CDH4,BNIP2,BOC,MEF2B |
| Myogenesis | CDON,TCF3B,TCF3A,MEF2AA,MYOG,MEF2B,TCF12,MYF6,BNIP2,BOC |
| Wnt Signaling Pathway NetPath | CSNK2A1P,TAX1BP3,BCL9,PAX2,MTAP1B,SALL1,MARK2,ANKRD6,TFAP2A,ROR2 |
| Developmental Biology | JAK3,RGMB,LGI2A,PAQR3A,MED25,ADAM22,TRPC3,EPHA2A,MYL12A,KCNQ2 |
| Corticotropin-releasing hormone | KRT14,CRHR2,TBX19,ADRBK2,JUND,CRH,TFAP2A,ECE1,CYP11B1,PARP1 |
| Neural Crest Differentiation | TXLNB,DMBX1,SOX10,DLX5,OLIG2,LHX1,LHX2,TFAP2B,GBX2,CDH6 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | KRT1,TLE2,HBP1,TLE4,AES,T,TLE1,TNIK,IGF2BP1,BCL9 |
Protein Function
TCF4 has several biochemical functions, for example, DNA binding,E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF4 itself. We selected most functions TCF4 had, and list some proteins which have the same functions with TCF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | VGLL3,FOXN3,PPM1A,SDCBP,TFCP2,TNNI3K,PDZD3,SIRT1,PFKM,VPS4A |
| protein heterodimerization activity | BHLHE40,SOS1,TERF1,HIST1H2BP,SYT14,H2-AB1,APITD1,Defa-rs7,HAND1,SPTA1 |
| protein binding | KIF5B,CD244,RAB3IP,FOSL2,ZNF398,CHRD,CCDC42,COG5,ZBTB48,PDE6D |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ATF4,HIF1A,ZFP292,NKX2-5,POU1F1,GATA2,IRF1,TRP53,ELF1,NR1H2 |
| bHLH transcription factor binding | USF2,HAND1,IKZF4,EP300,PSMD9,LMO2,SMAD3,SIRT1,SOX9,ASCL1 |
| transcription factor activity, sequence-specific DNA binding | SS18L1,ZNF483,BCL3,PRDM15,NME2,TEAD3,DMRTA1,GM239,HOXA13,KAT7A |
| protein homodimerization activity | TREX2,TFRC,NRBP1,KIF20B,FGFR1OP,S100A6,PVRL1,IDE,NR2F2,TGFB1 |
| DNA binding | HOXB8A,FOXO1B,H2AFB2,CRY1,PARP2,ARID1AA,SIX1B,TCF7L1B,ZBTB24,UHRF2 |
| E-box binding | TWIST1,ATOH8,ASCL1,C1orf51,MYC,TAL1,MYOD1,ARNTL2,LMO2,MYOG |
Interacting Protein
TCF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF4.
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References
- Kim, JT; Liu, CM; et al. Neurotensin, a novel target of Wnt/beta-catenin pathway, promotes growth of neuroendocrine tumor cells. INTERNATIONAL JOURNAL OF CANCER 136:1475-1481(2015).
- Sisirak, V; Ganguly, D; et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. JOURNAL OF EXPERIMENTAL MEDICINE 211:1969-1976(2014).
