SMAD7
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Official Full Name
SMAD family member 7 -
Overview
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SMAD7;SMAD family member 7;MAD, mothers against decapentaplegic homolog 7 (Drosophila) , MADH7, MADH8, SMAD, mothers against DPP homolog 7 (Drosophila);mothers against decapentaplegic homolog 7;hSMAD7;MAD homolog 8;mothers against DPP homolog 8;SM
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- Non
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SMAD7 involved in several pathways and played different roles in them. We selected most pathways SMAD7 participated on our site, such as TGF-beta signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | MAPK1,SMAD4,IFNG1-2,RBX1,SMAD9,SPAW,TGFBR2,BMP8B,ID3,GDF7 |
| Hippo signaling pathway | NF2,SOX2,SMAD2,FGF1,WNT1,GDF7,AXIN2,SNAI2,WNT5A,TGFBR2 |
Protein Function
SMAD7 has several biochemical functions, for example, I-SMAD binding,activin binding,beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD7 itself. We selected most functions SMAD7 had, and list some proteins which have the same functions with SMAD7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | SMAD6 |
| collagen binding | CD44,COMP,ITGA3,PCOLCE2,GP5,ITGA10,DDR1,C1QTNF1,PDGFB,PDGFA |
| activin binding | FKBP1A,TGFBR3,FST,FSTL3,SMURF1,ACVRL1,ACVR2B,ACVR1,ENG |
| type I transforming growth factor beta receptor binding | SMAD2,ENG,SNX25,TGFBR2,FKBP1A,TGFB1,TGFB3,SMAD6 |
| I-SMAD binding | AXIN2,TGFB1I1,SMAD6,AXIN1,SMAD4,SMAD1,TGFBR1,CTNNB1,SMURF1,SMAD2 |
| metal ion binding | YBEY,HIVEP2A,HIVEP2,SMPD2,ADNP2B,CLCNKA,RNF180,CYP21A1,CYGB1,TGFBR1B |
| ubiquitin protein ligase binding | UBXN1,BAG5,VCP,HERC2,TMEM189,SKI,RNF34,USP25,BAG4,STX8 |
| beta-catenin binding | FAM123B,C,CTNNA1,TCF7L1A,CDH2,CHD8,TAX1BP3,AXIN2,GSK3B,PXN |
| transcription regulatory region DNA binding | TP63,ATF3,ZNF174,TAF7,WNT11,REST,IKZF1,DDIT3,SALL2,TCF7L2 |
Interacting Protein
SMAD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD7.
COPS5;WWP2;FKBP1A;AXIN1
SMAD7 Related Signal Pathway
Resources
Gene Families
What Is Tumor Necrosis Factor (TNF)/TNF SuperfamilyWhat Is Tumor Necrosis Factor (TNF)/TNF Superfamily
TGF-β Superfamily Signaling
Research Area
Transcription Regulators in VSMCEpithelial Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Neural Stem Cell Transcription Factors
Intracellular Signaling Molecules in Angiogenesis
Mesenchymal to Epithelial Transition
Negative Regulators of EMT
BMPs (Bone Morphogenetic Proteins)
Related Services
Related Products
References
- Amiot, A; Peyrin-Biroulet, L; et al. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 8:66-82(2015).
- Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).
