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SMAD5

  • Official Full Name

    SMAD family member 5

  • Overview

    The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

  • Synonyms

    SMAD5;SMAD family member 5;DWFC;JV5-1;MADH5;mothers against decapentaplegic homolog 5;SMA- and MAD-related protein 5;SMAD, mothers against DPP homolog 5;MAD, mothers against decapentaplegic homolog 5;mothers against decapentaplegic, drosophila, homolog of, 5

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Mouse
  • Zebrafish
  • E.coli
  • E. coli
  • Mammalian Cell
  • Insect Cell
  • Insect Cells
  • HEK293
  • GST
  • His
  • Non
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SMAD5-2800H Recombinant Human SMAD5, GST-tagged E.coli Human GST C-term-305aa
SMAD5-001H Recombinant Human SMAD family member 5 Protein, His tagged E. coli Human His 155-258aa
SMAD5-1493H Recombinant Human SMAD Family Member 5, GST-tagged E.coli Human GST
SMAD5-162H Recombinant Human SMAD5 Protein, His-tagged E.coli Human His
SMAD5-2174C Recombinant Chicken SMAD5 Mammalian Cell Chicken His
SMAD5-31194TH Recombinant Human SMAD5 E.coli Human Non Full L. 1-465 a.a.
SMAD5-4333R Recombinant Rhesus monkey SMAD5 Protein, His-tagged Mammalian Cell Rhesus macaque His
SMAD5-479M Recombinant Mouse Smad5, Gly & Pro tagged Insect Cell Mouse His 2-465 a.a.
Smad5-8679M Recombinant Mouse Smad5, His-GST tagged Insect Cell Mouse GST 2-465 a.a.
SMAD5-8946Z Recombinant Zebrafish SMAD5 Mammalian Cell Zebrafish His
SMAD5-001MCL Recombinant Mouse SMAD5 cell lysate Insect Cell Mouse Non
SMAD5-303H Recombinant Human SMAD5 Protein, His-tagged E.coli Human His Gly210~Val464
Smad5-3220M Recombinant Mouse Smad5 protein(Thr2-Ser465) Insect Cells Mouse Non Thr2-Ser465
Smad5-3245M Recombinant Mouse Smad5 protein(Thr2-Ser465), His&GST-tagged Insect Cells Mouse His&GST Thr2-Ser465
SMAD5-4149R Recombinant Rhesus Macaque SMAD5 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
SMAD5-4149R-B Recombinant Rhesus Macaque SMAD5 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SMAD5-4899H Recombinant Human SMAD5 protein, His-tagged E. coli Human His 480aa(including fusion tag)
SMAD5-5870H Recombinant Human SMAD5 Protein (Gly210-Val464), His tagged E.coli Human His Gly210-Val464

    Involved Pathway

    SMAD5 involved in several pathways and played different roles in them. We selected most pathways SMAD5 participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells NODAL,INHBA,FGFR4,JARID2,MAPK3,ESX1,PIK3CG,FGFR3,HOXB1,WNT3
    TGF-beta signaling pathway BAMBIB,RHOAC,ACVR1,TGFB1A,BMP6,INHBB,SMURF2,LTBP1,SMAD3A,BMPR1BA

    Protein Function

    SMAD5 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD5 itself. We selected most functions SMAD5 had, and list some proteins which have the same functions with SMAD5. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding ATXN3,SUMO2,GLMN,DLG3,PML,HSPA1B,UBE2H,NEDD8,LC3,CUL4A
    RNA polymerase II core promoter sequence-specific DNA binding NSD1,TFAP2A,H2AFY,SUZ12,WBP2,RUNX2,FOS,GATA6,TP53,EP300
    protein binding HEMGN,GNB2,DIS3L2,SYCE1,MAGEB4,C14orf169,NPAS2,LNX2,TRIM23,CD209
    metal ion binding ZNF503,ZNF383,CDH15,ELOF1,ZBTB12,CYP2Y3,COX5B,CCDC76,ATP8B3,ZNRF2B
    DNA binding ING2,NTNG1,MSH4,NABP1A,GTF3A,BHLHA15,MXD4,HIST1H3A,HOXB8B,TOX
    transcription factor activity, sequence-specific DNA binding CLOCK,CREB5,CREB3L3L,NKX3-1,TBX16,TAF1B,IRF4,VDRB,TEF,NPAS1

    Interacting Protein

    SMAD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD5.

    SMAD5 Related Signal Pathway

    Resources

    Gene Families

    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily
    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily
    TGF-β Superfamily Signaling
    TGF-β Superfamily Signaling

    Research Area

    TGF-beta Family Modulator

    References

    • Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
    • Yao, QP; Zhang, P; et al. The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49:98-104(2014).

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