Slamf6
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Official Full Name
SLAM family member 6 -
Overview
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
SLAMF6;SLAM family member 6;lymphocyte antigen 108;KAL1;NTBA;KAL1b;Ly108;NTB-A;SF2000
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- HEK293
- Human Cell
- C-His
- E.coli
- Mammalian cells
- HEK293T
- His&Avi
- Fc
- Non
- hIgG4
- GST
- His
- His&Myc
- Myc&DDK
- His&mFc
- C-hFc-Flag
Involved Pathway
Slamf6 involved in several pathways and played different roles in them. We selected most pathways Slamf6 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with Slamf6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CRTAM,Mill2,LILRB4,CD96,CD200,SIGLEC11,CD200R3,CLEC2H,LILRB2,CD300E |
| Immune System | KIFAP3,GBP5,RAP1GAP2B,C1rb,KIF26A,SUGT1,WASF2,MYO1C,SEC61B,ATG7 |
| Adaptive Immune System | ASB18,PJA1,TRIM69,ASB6,GRAP2B,CTSE,DYNC1H1,KLRG1,SIGLEC11,HCST |
Protein Function
Slamf6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Slamf6 itself. We selected most functions Slamf6 had, and list some proteins which have the same functions with Slamf6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LETM1,ERC2,NEUROG1,ANKMY2,PEPD,SEPT5,STON2,PBRM1,TDRD1,HNRNPUL1 |
Interacting Protein
Slamf6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Slamf6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Slamf6.
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesNatural Killer Cell (NK Cell)
SLAM Family
Natural Killer T (NKT) Cells
Co-stimulatory Molecules
Related Services
Related Products
References
