SYT2
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Official Full Name
synaptotagmin II -
Overview
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in;the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)). -
Synonyms
SYT2;synaptotagmin II;synaptotagmin-2;Synaptotagmin 2;Synaptotagmin2;SynaptotagminII;SYT 2;Syt II;SYT2_HUMAN;SytII
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- Mammalian cells
- HEK293T
- In vitro E. coli expression system
- GST
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
SYT2 involved in several pathways and played different roles in them. We selected most pathways SYT2 participated on our site, such as Disease,Infectious disease,Neurotoxicity of clostridium toxins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Uptake and actions of bacterial toxins | ANTXR1,ANTXR2,PDCD6IP |
| Disease | CPSF6,OPN1SW,STRA6,RBP1,GPC6,BANF1,CUX1,PSIP1,HMGA1,CCDC167 |
| Infectious disease | IPO5,RCC1,STX1B,DOCK2,VPS37A,APOBEC3G,CPSF4,CHMP4B,NMT2,ANTXR2 |
| Neurotoxicity of clostridium toxins | STX1B |
Protein Function
SYT2 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT2 itself. We selected most functions SYT2 had, and list some proteins which have the same functions with SYT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| clathrin binding | SYT1A,SYT9,SYT4,AFTPHA,AP2B1,TOM1,SYT11,SYT7B,SYT17,CLINT1 |
| calcium ion binding | DLA,BNIP2,S100B,CDH9,FBLN1,EFCAB7,CAPNS1,CRELD1,ANXA1,PVALB2 |
| protein binding | ZNF394,DUSP9,NHLH2,CTSH,BCL2L1,GTF3C4,KRTAP13-3,KCNE1,SNX9,NPPB |
| calcium-dependent phospholipid binding | SYT3,ANXA6,ANXA5B,SYT17,SYT7,ANXA3B,RPH3AL,ANXA3,PCLO,SYT5B |
| inositol 1,3,4,5 tetrakisphosphate binding | ADAP1,ITPR3,ADAP2,AKR1C1 |
| syntaxin binding | STX16,ABL1,PLDN,PTPN2,SYT7,SYT10,STX6,DOC2D,CPLX2,CPLX4B |
Interacting Protein
SYT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT2.
HTT;PAUF;TGOLN2;PRKD2
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References
- Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
- Monterrat, C; Boal, F; et al. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1763:73-81(2006).
- HILBUSH, BS; MORGAN, JI; et al. A 3RD SYNAPTOTAGMIN GENE, SYT3, IN THE MOUSE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91:8195-8199(1994).
