SUV39H1
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Official Full Name
suppressor of variegation 3-9 homolog 1 (Drosophila) -
Overview
Human histone methyltransferase SUV39H1 is the homolog of the dominant Drosophila PEV modifier Su(var)3-9 and is composed of 412 amino acid residues (1). It combines two of the most evolutionarily conserved domains of the "chromatin regulators": the chrom -
Synonyms
SUV39H1;suppressor of variegation 3-9 homolog 1 (Drosophila);suppressor of variegation 3 9 (Drosophila) homolog 1 , SUV39H;histone-lysine N-methyltransferase SUV39H1;KMT1A;H3-K9-HMTase 1;Su(var)3-9 homolog 1;lysine N-methyltransferase 1A;histone H3-K9 methyltransferase 1;position-effect variegation 3-9 homolog;histone-lysine N-methyltransferase, H3 lysine-9 specific 1;MG44;SUV39H
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Mammalian Cell
- E.coli
- Sf9 Insect Cell
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
SUV39H1 involved in several pathways and played different roles in them. We selected most pathways SUV39H1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUV39H1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | ALDH1B1,PLOD1,HYKK.2,SETMAR,SETD1B,ALDH3A2,EHMT2,SETD8,MLL5,AGPHD1 |
Protein Function
SUV39H1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,S-adenosylmethionine-dependent methyltransferase activity,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUV39H1 itself. We selected most functions SUV39H1 had, and list some proteins which have the same functions with SUV39H1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | CDX1B,RXRB,NHLH2,TFAP2E,PLAGL1,RORA,ESX1,E2F7,RELB,ALX1 |
| transcription regulatory region sequence-specific DNA binding | SOX11,NR5A5,MEF2AA,SFPQ,KDM3A,KCNA3,PITX2,NFE2L3,NFE2L2B,POU2F1 |
| S-adenosylmethionine-dependent methyltransferase activity | PRMT7,LSM1,METTL7A,TPMT.2,MEPCE,WBSCR27,RRP8,PRMT8B,C6orf211,PRMT8 |
| protein binding | ATXN7,SCAF8,NFS1,HIPK4,POLR2C,TRIM74,TCL1A,ANKRA2,LNPEP,COPG |
| protein N-terminus binding | GLRX,NFE2,KCNQ2,TSC1,RELA,PHB2,LACRT,RASSF1,PARP1,ERCC2 |
| histone methyltransferase activity (H3-K9 specific) | SUV39H2,EHMT2,SETDB2,EHMT1 |
| histone methyltransferase activity | CARM1,EZH2,EED,PRMT1,PRMT6,PRMT2,SUZ12,PRDM13 |
| chromatin binding | CALCOCO1,MEF2A,PLAC8,TBL1Y,MEIS3,MTA3,TOP2A,PDX1,RBPJL,TGIF1 |
| histone-lysine N-methyltransferase activity | WHSC1L1,AAAS,EZH1,SETD8B,WBP7,SETD7,PRDM2,MLL1,SETDB1B,PRDM7 |
Interacting Protein
SUV39H1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUV39H1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUV39H1.
CBX5;HOOK2;KRTAP10-7;CEP70;LZTS2;BCL11B;MBD1
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References
- Kudithipudi, S; Kusevic, D; et al. Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains. CHEMMEDCHEM 9:554-559(2014).
- Wang, DL; Zhou, JY; et al. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:5516-5521(2013).
