SUFU
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Official Full Name
suppressor of fused homolog -
Overview
SUFU (Suppressor of Fused) was identified in Drosophila as a suppressor of the Fused (Fu) kinase that is essential for Hedgehog signaling during embryonic pattern formation (1). SUFU suppresses Hedgehog signaling by regulating the localization of the tran -
Synonyms
SUFU;suppressor of fused homolog (Drosophila);suppressor of fused homolog;PRO1280;SUFUH;SUFUXL
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SUFU involved in several pathways and played different roles in them. We selected most pathways SUFU participated on our site, such as Hedgehog signaling pathway,Pathways in cancer,Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUFU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog signaling pathway | WNT3,WNT7AA,SAP18,SKI,Shh,WNT11,BMP2B,PRKACAA,PRKACBA,GLI1 |
| Pathways in cancer | KITLG,GNG5,SOS1,CSF3R,BMP4,GNB2,MECOM,GNG8,PTGS2,TRAF4 |
| Basal cell carcinoma | HHIP,WNT5B,FZD9,WNT3A,Shh,WNT5A,GLI2,APC,WNT11,TCF7 |
Protein Function
SUFU has several biochemical functions, for example, protein binding,protein kinase binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SUFU itself. We selected most functions SUFU had, and list some proteins which have the same functions with SUFU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | TRAF4,STX1B,GPRC5B,AKAP1,MAP3K2,RB1CC1,B4GALT1,ELAVL1,CENPJ,MAP3K13 |
| protein binding | BCL2L15,PPP2R5B,KRTAP10-9,EIF4EBP3L,SPAG8,CYFIP2,DIEXF,NKD1,SELPLG,IL2RG |
| transcription factor binding | E2F5,MDFIC,PPP1R13BA,TP73,TCF3,KAT2B,HOXA7,SP100,TRIB1,IRF4 |
| transcription corepressor activity | TLE4,E4F1,ZNF593,BASP1,SSX1,HSF4,TMEM38A,NFKBIL2,E2F6,SIAH2 |
| signal transducer activity | PLCD1B,OPN1MW1,MTNR1AA,TAS2R138,GNG11,PPP1R12A,TAS2R108,TACR3A,TRHRB,NEK6 |
Interacting Protein
SUFU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUFU here. Most of them are supplied by our site. Hope this information will be useful for your research of SUFU.
GLI1
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