SRY
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Official Full Name
Sex Determining Region Y -
Overview
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. -
Synonyms
SRY;sex determining region Y;TDF;TDY;SRXX1;SRXY1;sex-determining region Y protein;testis-determining factor;sex-determining region on Y;sex determining region protein;essential protein for sex determination in human males;OTTHUMP00000034324
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SRY-454H | Recombinant Human SRY Protein, His-tagged | E.coli | Human | His | Met1~Leu204 | |
| SRY-16019M | Recombinant Mouse SRY Protein | Mammalian Cell | Mouse | His |
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| SRY-4480R | Recombinant Rhesus monkey SRY Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SRY-1469HCL | Recombinant Human SRY 293 Cell Lysate | HEK293 | Human | Non |
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| SRY-4296R | Recombinant Rhesus Macaque SRY Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SRY-4296R-B | Recombinant Rhesus Macaque SRY Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SRY-819M | Recombinant Mouse SRY Protein (1-144 aa), His-tagged | E.coli | Mouse | His | 1-144 aa |
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| SRY-8738M | Recombinant Mouse SRY Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SRY-8738M-B | Recombinant Mouse SRY Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SRY involved in several pathways and played different roles in them. We selected most pathways SRY participated on our site, such as Deactivation of the beta-catenin transactivating complex,Regulation of Androgen receptor activity,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | FGFBP3,OR2AP1,NOXO1,ANXA1A,RARG,LEO1,OXGR1A.3,C,PYGO1,PPY |
| TCF dependent signaling in response to WNT | RSPO4,WIF1,RNF43,SOX13,ZNRF3,RSPO1,TLE3B,SOX32,HECW1,CBY1 |
| Deactivation of the beta-catenin transactivating complex | PYGO2,TLE1,BCL9L,SOX4B,SOX9B,SOX7,BCL9,TLE4,RBBP5,SOX4A |
| Regulation of Androgen receptor activity | SPDEF,SMARCE1,APPBP2,NR0B1,HOXB13,KAT7,SMARCA2,GATA2,SENP1,NR2C2 |
| Signaling by Wnt | KREMEN2,LEO1,BCL9L,TNKS2,SOX9B,WNT8-2,PRICKLE1B,RBBP5,PRICKLE1,SOX4A |
Protein Function
SRY has several biochemical functions, for example, DNA binding,DNA binding, bending,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRY itself. We selected most functions SRY had, and list some proteins which have the same functions with SRY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | ARNT,PSMC5,FOSB,NLRP3,DRAP1,PPARGC1A,FOXO4,HES7,JUND,HOXA7 |
| protein heterodimerization activity | HIST1H4G,PDGFB,SMC3,UGT1A6A,TBX15,HIST1H2AB,TYRP1,IKZF3,MEF2C,HIST1H4I |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | ZFHX3,CIR1,BHLHE40,HNF4A,PKNOX1,GLI1,TFAP4,HIF1A,AHR,MEF2C |
| DNA binding | TTC5,ZFP692,DLX6A,ZNF563,SIX4B,HLF,ATRX,MXD3,POLR2J2,CDC5L |
| DNA binding, bending | HHEX,TOP2A,HMGB3,FOXD1,FOXL1,HMGB1,CRIP1,TOP2B,TERF1,FOXI1 |
| calmodulin binding | KCNH5,ASPM,SMTNL1,CNN3,IQCB1,MAP6,MYH7,TJP1,RASGRF2B,MAPKAPK2A |
Interacting Protein
SRY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRY here. Most of them are supplied by our site. Hope this information will be useful for your research of SRY.
SLC9A3R2;SMAD3
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References
- Willis, BC; Johnson, G; et al. SOX10: A Useful Marker for Identifying Metastatic Melanoma in Sentinel Lymph Nodes. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 23:109-112(2015).
- Frisch, J; Venkatesan, JK; et al. Determination of the Chondrogenic Differentiation Processes in Human Bone Marrow-Derived Mesenchymal Stem Cells Genetically Modified to Overexpress Transforming Growth Factor-beta via Recombinant Adeno-Associated Viral Vectors. HUMAN GENE THERAPY 25:1050-1060(2014).
