SPO11
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Official Full Name
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) -
Overview
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5 end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. -
Synonyms
SPO11;SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae);SPO11 meiotic protein covalently bound to DSB like (S. cerevisiae) , SPO11, meiotic protein covalently bound to DSB (S. cerevisiae) like;meiotic recombination protein SPO11;cancer/testis antigen 35;CT35;Meiotic recombination protein SPO 11;MGC39953;SPO 11;SPO11 meiotic protein covalently bound to DSB homolog;SPO11 meiotic protein covalently bound to DSB like
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPO11-11705Z | Recombinant Zebrafish SPO11 | Mammalian Cell | Zebrafish | His |
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| SPO11-1684HCL | Recombinant Human SPO11 cell lysate | Human | Non |
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| SPO11-3533H | Recombinant Human SPO11 protein, His-tagged | Insect cells | Human | His | 1-396aa |
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| SPO11-5211H | Recombinant Human SPO11 protein, His-tagged | E.coli | Human | His | 1-396aa |
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Involved Pathway
SPO11 involved in several pathways and played different roles in them. We selected most pathways SPO11 participated on our site, such as Cell Cycle,Meiosis,Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPO11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Meiotic recombination | MSH4,MND1,PSMC3IP,MSH5,DMC1,TEX15 |
| Meiosis | STAG2,FKBP6,MND1,SUN1,TEX15,DMC1,TERF2IP,SYCE1,TEX12,MSH5 |
| Cell cycle | CDC25A,ACD,CCP110,CENPC1,ORC2,CLASP1,RAD50,MAPRE1,PRKDC,POLD3 |
Protein Function
SPO11 has several biochemical functions, for example, ATP binding,DNA binding,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPO11 itself. We selected most functions SPO11 had, and list some proteins which have the same functions with SPO11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP668,HOPX,GTF2IRD2,SMARCC1B,PATZ1,PIAS4,NPAS2,RPP21,MAFA,FANCI |
| ATP binding | MKI67,PIP5K1B,ADCK2,ATP8B3,SLKA,GNE,UBE2E3,IRAK1,STK25A,CKBA |
| hydrolase activity | HE1A,KLK1B5,EHD2,HELZ,PLCD1A,PLA2G4AA,MPPED2A,ATP1A1A.4,NOTS,PNPLA5 |
Interacting Protein
SPO11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPO11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPO11.
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References
- Strong, ER; Schimenti, JC; et al. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. GENES 1:440-451(2010).
- Miura, C; Ohta, T; et al. Trypsin is a multifunctional factor in spermatogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:20972-20977(2009).
