SPAM1
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Official Full Name
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -
Overview
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement;membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3;and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol;SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme;located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that;enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that;plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida;adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes;leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for;this gene. -
Synonyms
SPAM1;sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding);sperm adhesion molecule 1;HYA1;HYAL PH-20;HYAL PH20;Hyal-PH20;HYAL1;HYAL3;HYAL5;HYALP_HUMAN;Hyaluronidase PH-20;Hyaluronoglucosaminidase PH-20;MGC26532;PH-20 Hyaluronidase;PH20;PH20 Hyaluronidase;SPAG15;SPAM-1;Sperm surface protein PH-20;Sperm surface protein PH20;zona pellucida binding;hyaluronidase, zona pellucida binding;PH-20
Recombinant Proteins
- Human
- Bovine
- Mouse
- Zebrafish
- Rat
- Ovine
- Human
- HEK293
- CHO
- E.coli
- Mammalian Cell
- Ovine Testis
- HEK293T
- Mammalian cells
- His&Fc
- His
- Non
- Fc
- His&SUMO
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SPAM1 involved in several pathways and played different roles in them. We selected most pathways SPAM1 participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | IDS,HEXA,IDUA,HYAL4,HYAL3,HYAL6,HYAL1,HPSE,HGSNAT,HEXB |
| Metabolic pathways | ATP6V1H,NME2B.2,URAH,HSD17B1,MTMR8,ALOX12B,ATP6V0C,HSD3B4,MRI1,PTGES3B |
Protein Function
SPAM1 has several biochemical functions, for example, hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAM1 itself. We selected most functions SPAM1 had, and list some proteins which have the same functions with SPAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hyalurononglucosaminidase activity | HYAL1,HYAL2,KIAA1199,MGEA5,HYAL3,HYAL4,CD44,HYAL6 |
Interacting Protein
SPAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAM1.
hyaluronan
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References
- Blondeau, JJC; Deng, M; et al. Identification of novel long non-coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015).
- Yoon, S; Chang, KT; et al. Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay. ANIMAL REPRODUCTION SCIENCE 150:107-114(2014).
