SNAI2
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Official Full Name
snail homolog 2 (Drosophila) -
Overview
Function: SNAIL is involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm (By similarity). Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. SLUG is a transcriptional repressor, involved in the generation and migration of neural crest cells. PTM: SNAIL is phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Similarity: Both SNAIL and SLUG belong to the snail C2H2-type zinc-finger protein family. Tissue specificity: SNAIL is expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. SLUG is expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. -
Synonyms
SNAI2;snail homolog 2 (Drosophila);SLUG, slug homolog, zinc finger protein (chicken);zinc finger protein SNAI2;SLUGH1;SNAIL2;protein snail homolog 2;neural crest transcription factor SLUG;slug (chicken homolog), zinc finger protein;SLUG;WS2D;M
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SNAI2 involved in several pathways and played different roles in them. We selected most pathways SNAI2 participated on our site, such as Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNAI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | SSX2IPA,CTNNA1,CTNNB1,IGF1RA,MAPK3,CREBBP,RAC3A,WASLB,ACTG1,RAC1 |
| Hippo signaling pathway | CDH1,FZD10,FBXW11,APC,AXIN2,ITGB2L,BMP4,PPP1CB,SAV1,CCND2 |
Protein Function
SNAI2 has several biochemical functions, for example, chromatin binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNAI2 itself. We selected most functions SNAI2 had, and list some proteins which have the same functions with SNAI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | GTF2IRD1,NKX2-5,MEF2A,FOXF1,TEAD2,SFPI1,CEBPB,PTH,HIF1A,LEF1 |
| chromatin binding | MECP2,CBX1,PHF8,ASH1L,DNAJC2,DNMT3B,RFX4,JUN,NFKB2,APBB1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SFPI1,KCNIP3,TGIF1,REST,CC2D1A,NFIL3-5,NR1D1,NR2E1,ZNF148,POU4F2 |
| protein binding | GPSM2,SNX2,SYTL4,FCN2,HNRNPU,C6orf130,PITPNM1,MED14,THOC4,FIBPB |
| metal ion binding | ATP13A4,ZNF831,PPARG,ZNF576,CAR6,CASZ1,KCNIP1B,LIMCH1B,CDKN1A,LATS2 |
| sequence-specific DNA binding | TFCP2L1,CENPB,ZNF263,DLX2B,CREB3L3A,CDX1A,NR5A1B,EMX2,NANOG,FOXL2 |
Interacting Protein
SNAI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNAI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNAI2.
TRIM23;SAT;vdr_human_gene
Resources
Research Area
Early Mesodermal Lineage MarkersTranscription Factors in the Akt Pathway
Neural Crest Cell Markers
Ectodermal Lineage Markers
Mesodermal Lineage Markers
Related Services
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References
- Maurer, J; Nelson, B; et al. Contrasting Expression of Keratins in Mouse and Human Embryonic Stem Cells. PLOS ONE 3:-(2008).
- Li, ZD; Wermuth, PJ; et al. Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro. AMERICAN JOURNAL OF PATHOLOGY 182:325-331(2013).
