SMUG1
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Official Full Name
single-strand-selective monofunctional uracil-DNA glycosylase 1 -
Overview
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. -
Synonyms
SMUG1;single-strand-selective monofunctional uracil-DNA glycosylase 1;single-strand selective monofunctional uracil DNA glycosylase;FDG;HMUDG;UNG3;MGC104370;Single strand selective monofunctional uracil DNA glycosylase 1;Single strand selective monofunctional uracil DNA glycosylase;SMUG 1;SMUG1 protein;SMUG1_HUMAN;UNG 3
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
SMUG1 involved in several pathways and played different roles in them. We selected most pathways SMUG1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMUG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | xthA,FEN1,MUTYH,LIG3,POLE4,POLE2,TDG.1,UNG,HMGB1A,POLE |
Protein Function
SMUG1 has several biochemical functions, for example, DNA N-glycosylase activity,DNA binding,oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMUG1 itself. We selected most functions SMUG1 had, and list some proteins which have the same functions with SMUG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX2-5,BANP,THOC1,TAF1L,MYCN,HOXB13A,HIST2H4A,ISL1L,MEF2CB,ZNF469 |
| uracil DNA N-glycosylase activity | TDG.1,CCNO,TDG,UNGA,APEX1,UNG |
| DNA N-glycosylase activity | NEIL1,NEIL3,NTHL1,TDG,OGG1 |
| oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | NTHL1 |
| protein binding | C7orf50,BCL9,PPIL2,KRT5,CUEDC2,PTPN3,ATF3,KREMEN1,JUP,VAT1L |
Interacting Protein
SMUG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMUG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMUG1.
VAC14;RBPMS;vpr;TRIP13
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References
- Maul, RW; Gearhart, PJ; et al. Refining the Neuberger model: Uracil processing by activated B cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1913-1916(2014).
- Pettersen, HS; Galashevskaya, A; et al. AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA REPAIR 25:60-71(2015).
