SMC3
-
Official Full Name
structural maintenance of chromosomes 3 -
Overview
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008] -
Synonyms
SMC3;structural maintenance of chromosomes 3;BAM;BMH;HCAP;CDLS3;CSPG6;SMC3L1;structural maintenance of chromosomes protein 3;SMC protein 3;chromosome-associated polypeptide;chondroitin sulfate proteoglycan 6 (bamacan);basement membrane-associated chondroitin proteoglycan
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- His
- His&T7
- GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMC3-2810H | Recombinant Human SMC3, His-tagged | E.coli | Human | His | 1-349aa | |
| SMC3-12720Z | Recombinant Zebrafish SMC3 | Mammalian Cell | Zebrafish | His |
|
|
| SMC3-1541H | Recombinant Human SMC3 protein, His & T7-tagged | E.coli | Human | His&T7 | Ser994~Glu1181 |
|
| SMC3-20H | Recombinant Human SMC3, GST-tagged | Wheat Germ | Human | GST |
|
|
| SMC3-31196TH | Recombinant Human SMC3, His-tagged | E.coli | Human | His | 233-736 a.a. |
|
| SMC3-6086C | Recombinant Chicken SMC3 | Mammalian Cell | Chicken | His |
|
|
| SMC3-1648HCL | Recombinant Human SMC3 cell lysate | Human | Non |
|
||
| SMC3-6688H | Recombinant Human SMC3 Protein (Glu995-Glu1181), N-His tagged | E.coli | Human | His | Glu995-Glu1181 |
|
Involved Pathway
SMC3 involved in several pathways and played different roles in them. We selected most pathways SMC3 participated on our site, such as Cell cycle,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | CALM1A,CPEB1,PPP2CA,CCNB2,Ar,SLKA,MAPK12B,CPEB1B,PRKACBB,PLCZ1 |
| Cell cycle | NIPBLB,OIP5,GADD45G,TUBB4A,CDCA8,CDKN2C,KIF20A,NUDC,PKMYT1,TERF2 |
Protein Function
SMC3 has several biochemical functions, for example, ATP binding,chromatin binding,dynein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMC3 itself. We selected most functions SMC3 had, and list some proteins which have the same functions with SMC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dynein binding | KATNA1,PAFAH1B1B,DCTN1,KATNB1,NEFH,DNAAF1,PAFAH1B1A,DCTN6,SERPINB1A,LRRC50 |
| ATP binding | GRK6,TTBK2,NAIP1,NARS,NEK10,FGR,PFKFB2,MYH9,DDX3X,CCT3 |
| mediator complex binding | SMC1A,NIPBL,MED1 |
| microtubule motor activity | KIF22,KLC1,DNAH5,DYNC1LI2,KIF20B,KIF5C,KIF26A,KIF21A,DYNC1I2,KIF7 |
| protein heterodimerization activity | SOX9,PANX1,KCNK3,HIST1H4C,DMRT3A,NFE2L2A,SYT16,POU5F3,HIST1H4I,JDP2 |
| chromatin binding | LDB1,SLC30A9,POLR3D,RAN,POU2F1,CUX1,HOXC13,STAG2,NCAPD2,RNF2 |
| protein binding | NT5C2,TJP1,OFD1,DZIP1L,PDLIM2,RAP1GAP,TGFB1,PLXNC1,FAM49B,UBE2E1 |
Interacting Protein
SMC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMC3.
RAD21;STAG1
Resources
Related Services
Related Products
References
- del Cacho, E; Gallego, M; et al. Location of RAD51-like protein during meiotic prophase in Eimeria tenella. VETERINARY PARASITOLOGY 178:77-85(2011).
- Bermudez, VP; Farina, A; et al. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:9366-9371(2012).
