SLIT2
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Official Full Name
slit homolog 2 (Drosophila) -
Overview
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. -
Synonyms
SLIT2;slit homolog 2 (Drosophila);SLIL3, slit (Drosophila) homolog 2;slit homolog 2 protein;Slit 2;SLIL3;Slit-2;FLJ14420
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- CHO
- HEK293
- Mammalian Cell
- E.coli
- Mammalian cells
- HEK293T
- Non
- His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SLIT2 involved in several pathways and played different roles in them. We selected most pathways SLIT2 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLIT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | CXCR4,CSNK2B,Ntng2,EPHA6,EFNA2,ARPC1A,ACTR2,AP2A2,CLTB,DPYSL2B |
Protein Function
SLIT2 has several biochemical functions, for example, GTPase inhibitor activity,Roundabout binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLIT2 itself. We selected most functions SLIT2 had, and list some proteins which have the same functions with SLIT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase inhibitor activity | TNK2,ARL2,CDC42SE1,UBE4A,RTKN,PDE6D,GPS1,CPEB2,RHOH,IPO5 |
| heparin binding | SERPIND1,CYR61,PTCH1,SELP,AAMP,CLEC3B,OVALX,NRP2,PF4,PCSK6 |
| proteoglycan binding | CTSK,FCN2,COL5A1,NID1,UBE4A,CTSB,CTSL1,CTSS,CECR1,THBS1 |
| calcium ion binding | RHOT1A,TMEM8C,PCDH2G3,RHOT1B,PVALB4,GUCA1A,SWAP70,ANXA3B,S100A10B,S100A4 |
| heparan sulfate proteoglycan binding | HRG,GPC1,AZU1,AGRN,GPC1A,GPC3,ITGAM,COMP,Gpc2,CFH |
| Roundabout binding | TGFB1I1,SLIT1,GM4980,SLIT1B,UBE4A,SLIT1A,SLIT3 |
| laminin-1 binding | LACRT,NTN4,NID1,Shh,DAG1,UBE4A |
| protein homodimerization activity | KCNK9,DGAT2,ERN1,Il6ra,PRMT2,ENPP1,VIL1,AOC3,MAP3K13,CARD8 |
| protein binding | SLC48A1,PRKACA,SPRR3,SCARF1,CMTM3,STEAP3,SCIMP,AVPR2,CORO6,ARL2BP |
Interacting Protein
SLIT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLIT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLIT2.
ETS1;BILF1;mgtA;yfiS;q8clc4_yerpe;q9wmx2-pro_0000037546;q9wmx2-pro_0000037548;MYC
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References
- Pircher, A; Wellbrock, J; et al. New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules. ONCOLOGY 86:46-52(2014).
- Qi, CL; Lan, HM; et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. LABORATORY INVESTIGATION 94:766-776(2014).
