SLC7A5
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Official Full Name
solute carrier family 7 (amino acid transporter light chain, L system), member 5 -
Overview
L-type amino acid transporter 1 (LAT1), also known as Solute carrier family 7 member 5 (SLC7A5), is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner and selectively tr -
Synonyms
SLC7A5;solute carrier family 7 (amino acid transporter light chain, L system), member 5;large neutral amino acids transporter small subunit 1;CD98;D16S469E;E16;LAT1;MPE16;4F2 LC;4F2 light chain;CD98 light chain;integral membrane protein E16;L-
Recombinant Proteins
- Mouse
- Chicken
- Human
- Rat
- Zebrafish
- Mammalian Cell
- HEK293T
- Insect Cell
- E.coli
- HEK293
- His
- Myc&DDK
- His&Flag&MBP
- GST
- His&Myc&SUMO
- His&Fc&Avi
Involved Pathway
SLC7A5 involved in several pathways and played different roles in them. We selected most pathways SLC7A5 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC7A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | MAPK3,ERBB2,PIK3R2,LDHA,GLS,HK2,NTRK3,PDGFRB,PFKM,FLT3 |
Protein Function
SLC7A5 has several biochemical functions, for example, L-amino acid transmembrane transporter activity,L-leucine transmembrane transporter activity,L-phenylalanine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC7A5 itself. We selected most functions SLC7A5 had, and list some proteins which have the same functions with SLC7A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antiporter activity | SLC4A8,CLCN6,SLC7A3,SLC35D2,SLC35E2,CLCN3,CLCN5,SLC35D1A,SLC7A14,SLC9A5 |
| amino acid transmembrane transporter activity | SLC7A14,SLC38A2,SLC38A6,SLC7A3A,SLC38A5,SLC38A11,SLC36A4,PEX3,SLC38A4,SLC38A9 |
| L-amino acid transmembrane transporter activity | Nat3,SLC43A1A,SLC7A8,SLC7A6,SLC38A7,SLC7A14,SLC43A2B,SLC7A13,SLC7A7,SLC43A2 |
| L-tryptophan transmembrane transporter activity | SLC36A4 |
| L-leucine transmembrane transporter activity | SLC38A7 |
Interacting Protein
SLC7A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC7A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC7A5.
Resources
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References
- Ikotun, OF; Marquez, BV; et al. Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET. PLOS ONE 8:-(2013).
- Galluccio, M; Pingitore, P; et al. Cloning, Large Scale Over-Expression in E-coli and Purification of the Components of the Human LAT 1 (SLC7A5) Amino Acid Transporter. PROTEIN JOURNAL 32:442-448(2013).
