SLC39A7
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Official Full Name
solute carrier family 39 (zinc transporter), member 7 -
Overview
Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments. -
Synonyms
SLC39A7;solute carrier family 39 (zinc transporter), member 7;HKE4, HLA class II region expressed gene KE4;zinc transporter SLC39A7;D6S2244E;H2 KE4;KE4;RING5;ZIP7;D6S115E;Histidine rich membrane protein Ke4;Histidine-rich membrane protein Ke4;HKE4;HLA class II region expressed gene KE4;Ke4 gene mouse, human homolog of;Really interesting new gene 5 protein;S39A7_HUMAN;Solute carrier family 39 member 7;solute carrier family 39 zinc transporter member 7;Ke4 gene, mouse, human homolog of;H2-KE4
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Mus musculus
- Dog
- Sus scrofa (Pig)
- zebrafish
- Pongo Abelii
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- HEK293T
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Flag&MBP
- His&Fc&Avi
- GST
Involved Pathway
SLC39A7 involved in several pathways and played different roles in them. We selected most pathways SLC39A7 participated on our site, such as Metal ion SLC transporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC39A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SLC-mediated transmembrane transport | SLC9A9,SLC26A6L,SLC1A7B,SLC28A3,LCN1,SLC13A4,PDZD11,SLC24A5,SLC2A10,LCN9 |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC6A18,RHAG,SLC30A3,SLC31A1,SLC6A9,SLC30A6,SLC13A3,RHCG2A,RHBG,SLC30A1A |
| Zinc transporters | SLC39A8,SLC39A2,SLC39A1,SLC30A3,SLC30A2,SLC39A10,SLC39A14,SLC30A1B,SLC39A5,SLC39A3 |
| Zinc influx into cells by the SLC39 gene family | SLC39A5,SLC39A3,SLC39A14,SLC39A10,SLC39A2,SLC39A8,SLC39A6,SLC39A1 |
| Transmembrane transport of small molecules | AQP1A.2,ANO10A,WNK1,SLC2A13B,SLC35A2,SLC35B3,SLC24A6,ADD3,MFSD7B,NIPAL3 |
| Metal ion SLC transporters | SLC30A6,SLC30A3,SLC31A1,CP,SLC39A10,SLC39A5,SLC39A8,SLC39A6,SLC30A1B,SLC39A1 |
Protein Function
SLC39A7 has several biochemical functions, for example, protein binding,zinc ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC39A7 itself. We selected most functions SLC39A7 had, and list some proteins which have the same functions with SLC39A7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HIPK4,PTTG1IP,ARL2BP,RRP8,PTPN23,E2F3,UBE2D1,VSIG4,RSPH9,CASC3 |
| zinc ion transmembrane transporter activity | SLC39A10,SLC39A2,SLC30A8,SLC39A1,SLC30A10,SLC11A2,SLC30A4,SLC30A1A,SLC39A14,SLC30A2 |
Interacting Protein
SLC39A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC39A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC39A7.
CSNK2A1;RGS20;CD40;USP49;YY1;Kcnk1;ERBB2;Eef1a1;MAD2L1;Cul4a;Atp7a;MBOAT1;P;Tmed2
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References
- Galora, S; Saracini, C; et al. Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients. JOURNAL OF VASCULAR SURGERY 61:787-792(2015).
- Jiang, CD; Liu, YG; et al. Molecular Cloning, Sequence Identification and Tissue Expression Profile of Three Novel Sheep (Ovis aries) Genes SLC39A1, SLC39A2 and SLC39A7. JOURNAL OF ANIMAL AND VETERINARY ADVANCES 10:2699-2705(2011).
