SLC2A1
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Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 1 -
Overview
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013] -
Synonyms
SLC2A1;solute carrier family 2 (facilitated glucose transporter), member 1;PED;DYT9;GLUT;DYT17;DYT18;EIG12;GLUT1;HTLVR;GLUT1DS;solute carrier family 2, facilitated glucose transporter member 1;GLUT-1;hepG2 glucose transporter;glucose transporter type 1, erythrocyte/brain;human T-cell leukemia virus (I and II) receptor
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- Protein Conjugation
- Mamanlian cells
- HEK293T
- His
- His&SUMO
- Myc&DDK
- Non
- His&Myc
- Flag
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
SLC2A1 involved in several pathways and played different roles in them. We selected most pathways SLC2A1 participated on our site, such as HIF- signaling pathway,Insulin secretion,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | ETS1,PIK3R5,EP300,PIK3CB,PAK7,RAF1,FH,BRAF,PTPN11,AKT2 |
| Insulin secretion | CAMK2A,CAMK2B,SLC2A2,PCLO,PRKACB,CAMK2D,ATP1A3,PRKACG,CREB3L2,PRKACA |
| Bile secretion | ADCY3,SLCO1A5,Adcy4,ATP1A1,AQP8,ADCY6,OSTA,CYP3A4,CA2,ATP1B4 |
| Central carbon metabolism in cancer | MET,PIK3CG,PDHB,MAPK1,PGAM1,PDGFRB,PIK3CA,IDH1,MAP2K2,PFKL |
| HIF- signaling pathway | ENO2,MKNK1,FLT1,ARNT,CUL2,TCEB2,HKDC1,RPS6,PRKCB,PLCG1 |
| HTLV-I infection | Il2,TNFRSF1A,TNFRSF13C,ANAPC1,PDGFB,IL2RB,TBPL1,ZFP36,HLA-DPA1,PTTG1 |
| Thyroid hormone signaling pathway | GSK3B,DIO3,TSC2,PIK3R1,PRKCG,MED12,MDM2,MAPK3,SLC16A10,SRC |
| Insulin resistance | PPARAB,PTEN,SLC27A1B,OGT,GYS1,INS,NR1H2,SLC2A1A,PCK1,MAPK9 |
| Pathways in cancer | PRKCB,HSP90AB1,WNT3A,WNT8B,KRAS,GNG2,WNT4,MAP2K1,MAP2K2,PLCB3 |
Protein Function
SLC2A1 has several biochemical functions, for example, D-glucose transmembrane transporter activity,dehydroascorbic acid transporter activity,glucose transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC2A1 itself. We selected most functions SLC2A1 had, and list some proteins which have the same functions with SLC2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PTPN11,PFTK1,HIPK4,S100A8,EIF3D,AHNAK,HERPUD1,WASF1,SPPL2B,VCL |
| D-glucose transmembrane transporter activity | SLC2A4,SLC2A13B,SLC2A2 |
| kinase binding | PRKCD,CAB39,SRC,UBQLN1,HPCA,RASGRP3,SIT1,BARD1,PARK2,MIDN |
| identical protein binding | HGF,DHX8,ERBB2,MICU1,ACTB,HOOK3,APOH,DVL2,MNS1,KCNJ2 |
| protein self-association | ZKSCAN17,TRIM32,CTSC,BCL10,PCSK9,ACHE,TRP53,CTSB,ZSWIM2,NKX3 |
| dehydroascorbic acid transporter activity | SLC2A2,SLC23A1 |
| glucose transmembrane transporter activity | SLC2A3A,SLC2A5,SLC2A4,SLC2A3,SLC2A6,SLC2A11L,SLC2A9L1,PPBP,SLC2A2,SLC2A15A |
Interacting Protein
SLC2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC2A1.
VCAM1;COPS6;E2F3;JAK2;STK17B;ATF2;TYK2;Bmpr1a;Cct8
Resources
Research Area
Uptake and Transport Molecules on Endothelial CellsUptake and Transport Molecules in VSMC
Glycolysis
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References
