SLC27A2

  • Official Full Name

    solute carrier family 27 (fatty acid transporter), member 2

  • Overview

    The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

  • Synonyms

    SLC27A2;solute carrier family 27 (fatty acid transporter), member 2;VLCS;FATP2;VLACS;ACSVL1;FACVL1;hFACVL1;HsT17226;very long-chain acyl-CoA synthetase;FATP-2;THCA-CoA ligase;fatty acid transport protein 2;long-chain-fatty-acid--CoA ligase;solute carrier family 27 member 2;very-long-chain acyl-CoA synthetase;very long-chain-fatty-acid-CoA ligase;very long-chain fatty-acid-coenzyme A ligase 1;fatty-acid-coenzyme A ligase, very long-chain 1

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mus musculus
  • Mammalian Cell
  • HEK293
  • E.coli expression system
  • Yeast
  • HEK293T
  • E.coli
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • His&SUMO

    Involved Pathway

    SLC27A2 involved in several pathways and played different roles in them. We selected most pathways SLC27A2 participated on our site, such as Alpha-oxidation of phytanate,Bile acid and bile salt metabolism,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC27A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Peroxisome ACSL1A,ACAA1A,PECR,PEX3,NOS2,ACSL1B,PXMP2,HAO2,NUDT7,AMACR
    Peroxisomal lipid metabolism CRAT,SLC27A2A,SCP2B
    Insulin resistance CREB1A,PPP1R3DA,PTENB,PTPN1,PPP1CC,SOCS3B,TBC1D4,PRKCD,OGT,IRS2
    Bile acid and bile salt metabolism CYP7A1,BRSK2,AKR1C2,ACOT8,SLC27A2A,SLCO1B1,AKR1C6,AKR1C21,AKR1C4,CYP8B2
    Metabolism SLC44A5B,CSNK1G2,COX18,NUDT4,ALOX5B.2,SLC26A1,KCNS3A,CYP3C1,COX14,LOC100686744
    Metabolism of lipids and lipoproteins CDK19,AGPAT6,DGAT1B,NFYAL,MED26,MED18,ACOT8,AKR1C6,MED16,CYP46A1
    PPAR signaling pathway ACSL3B,FABP1,CYP4A10,CPT1C,ADIPOQ,PPARDB,PPARG,ANGPTL4,FABP6,ILK
    Alpha-oxidation of phytanate SLC27A2A

    Protein Function

    SLC27A2 has several biochemical functions, for example, ATP binding,enzyme binding,fatty acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC27A2 itself. We selected most functions SLC27A2 had, and list some proteins which have the same functions with SLC27A2. You can find most of the proteins on our site.

    Function Related Protein
    long-chain fatty acid-CoA ligase activity ACSBG2,SLC27A1B,ACSL4,ACSBG1,SLC27A4,ACSL5,ACSL1,SLC27A1A,ACSL3,SLC27A3
    enzyme binding PICK1,CTNNB1,CYB5A,UGT1A4,HLCS,PIAS1,Txn1,YWHAH,CABYR,DIS3L
    ATP binding KARS,NLRP5,UBE2R2,MADD,LIG4,ADCY8,MARK3,CAMK2B,NLRP1,ACSM4
    very long-chain fatty acid-CoA ligase activity SLC27A5,SLC27A3,SLC27A4,SLC27A1A,ACSL4,ACSBG1,SLC27A1B
    receptor binding CNPY4,CD276,GSTM7,C3,PTK6B,RND1,NMU,NPPC,SLC9A3R2,CNPY3
    fatty acid transporter activity SLC27A1A,SLC27A1B,SLC27A4,SLC27A5

    Interacting Protein

    SLC27A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC27A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC27A2.

    YWHAZ;purL;Ubr5;ssrna_ug;SLC33A1;CCNB1;CTDSPL2;KPNB1;Tnpo1;SPC24;FAM134A

    Resources

    Research Area

    Lipid and Fatty Acid Transport
    Adipogenesis Markers

    References

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