SLC12A5
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Official Full Name
solute carrier family 12 (potassium/chloride transporter), member 5 -
Overview
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
SLC12A5;solute carrier family 12 (potassium/chloride transporter), member 5;solute carrier family 12 member 5;KCC2;KIAA1176;hKCC2;K-Cl cotransporter 2;neuronal K-Cl cotransporter;erythroid K-Cl cotransporter 2;electroneutral potassium-chloride co
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC12A5-15211M | Recombinant Mouse SLC12A5 Protein | Mammalian Cell | Mouse | His |
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| SLC12A5-5426R | Recombinant Rat SLC12A5 Protein | Mammalian Cell | Rat | His |
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| SLC12A5-1805HCL | Recombinant Human SLC12A5 293 Cell Lysate | HEK293 | Human | Non |
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| SLC12A5-301559H | Recombinant Human SLC12A5 protein, GST-tagged | E.coli | Human | GST | Ile915-Asn1043 |
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| SLC12A5-5085R | Recombinant Rat SLC12A5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC12A5-5085R-B | Recombinant Rat SLC12A5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Slc12a5-5904M | Recombinant Mouse Slc12a5 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SLC12A5-8218M | Recombinant Mouse SLC12A5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC12A5-8218M-B | Recombinant Mouse SLC12A5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC12A5 involved in several pathways and played different roles in them. We selected most pathways SLC12A5 participated on our site, such as GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | GNG5,SLC38A2,GNG7,GABRB3,GNAI2,GABRA3,GABBR1,GNB1,GABRP,PRKACA |
Protein Function
SLC12A5 has several biochemical functions, for example, potassium ion symporter activity,potassium:chloride symporter activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A5 itself. We selected most functions SLC12A5 had, and list some proteins which have the same functions with SLC12A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | AXIN2,PPP1R12B,CAMK2N2,SYK,TRIM6,HDAC7A,CALM3,PTPRR,CDC42,CDK5RAP2 |
| potassium:chloride symporter activity | SLC12A10.2,SLC12A10.3,SLC12A1,SLC12A2,SLC12A5B,SLC12A7,SLC12A10.1,SLC12A4,SLC12A8 |
| potassium ion symporter activity | SLC12A2,SLC12A7,SLC12A1,SLC12A5B,SLC12A10.3,SLC12A4,SLC12A10.1,SLC12A10.2,SLC12A8 |
Interacting Protein
SLC12A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A5.
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References
- Robel, S; Buckingham, SC; et al. Reactive Astrogliosis Causes the Development of Spontaneous Seizures. JOURNAL OF NEUROSCIENCE 35:3330-3345(2015).
- Yu, C; Yu, J; et al. Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. CELL RESEARCH 24:701-712(2014).
