SLC11A1
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Official Full Name
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 -
Overview
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. -
Synonyms
SLC11A1;solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1;LSH, NRAMP, NRAMP1;natural resistance-associated macrophage protein 1;natural resistance associated macrophage protein 1;LSH;NRAMP 1;NRAMP;PBC;Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1;solute carrier family 11 (sodium/phosphate symporters) member 1;Solute carrier family 11 member 1;OTTHUMP00000109205;solute carrier family 11 (sodium/phosphate symporters), member 1;NRAMP1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Pig
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293
- E.coli
- GST
- His
- Non
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC11A1 involved in several pathways and played different roles in them. We selected most pathways SLC11A1 participated on our site, such as Lysosome,Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | MT1X,ATP1B2,ATP1A4,ATP1B3,MT1M,HEPH,HMOX1,MT2,Trf,SLC30A1 |
| Lysosome | GUSB,LGMN,DNASE2A,MFSD8,CTNS,M6PR,CTSJ,CTSBA,PSAPL1,SMPD1 |
Protein Function
SLC11A1 has several biochemical functions, for example, manganese ion transmembrane transporter activity,metal ion:proton antiporter activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A1 itself. We selected most functions SLC11A1 had, and list some proteins which have the same functions with SLC11A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | ADD1,E2F8,BHLHE40,SNX2,BMPR1A,MGLL,HPS4,ADAM10,IL6R,BCL2L1 |
| transition metal ion transmembrane transporter activity | SLC11A2 |
| manganese ion transmembrane transporter activity | MMGT2,ZP3,SLC11A2,TRPM2 |
Interacting Protein
SLC11A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A1.
Resources
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References
- Iacoboni, PA; Hasenauer, FC; et al. Polymorphisms at the 3' untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 160:230-234(2014).
- Masala, S; Cossu, D; et al. Recognition of zinc transporter 8 and MAP3865c homologous epitopes by new-onset type 1 diabetes children from continental Italy. ACTA DIABETOLOGICA 51:577-585(2014).
