SHBG
-
Official Full Name
sex hormone-binding globulin -
Overview
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SHBG;sex hormone-binding globulin;ABP;androgen binding protein;MGC126834;MGC138391;TEBG;SBP;Sex steroid binding protein;Sex steroid-binding protein;SHBG_HUMAN;Testis specific androgen binding protein;Testis-specific androgen-binding protein;Testosterone binding beta globulin;Testosterone Estradiol Binding Globulin;Testosterone estrogen binding globulin;Testosterone-estradiol-binding globulin;Testosterone-estrogen-binding globulin;OTTHUMP00000135293;testosterone-binding beta-globulin
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Human Serum
- E.coli
- Mammalian Cell
- CHO
- HEK293F
- HEK293 cells
- HEK293
- Human pregnancy Plasma
- HEK293T
- Mammalian cells
- Non
- His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SHBG involved in several pathways and played different roles in them. We selected most pathways SHBG participated on our site, such as Nongenotropic Androgen signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SHBG has several biochemical functions, for example, androgen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHBG itself. We selected most functions SHBG had, and list some proteins which have the same functions with SHBG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen binding | Ar,TSPO,ALDH1A1 |
Interacting Protein
SHBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHBG here. Most of them are supplied by our site. Hope this information will be useful for your research of SHBG.
GRB2;CLEC4G;d-mannose
Resources
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References
- Chiesa, A; Olcese, MC; et al. Variable clinical presentation and outcome in pediatric patients with resistance to thyroid hormone (RTH). ENDOCRINE 41:130-137(2012).
- Schmidt, J; Brannstrom, M; et al. Reproductive Hormone Levels and Anthropometry in Postmenopausal Women with Polycystic Ovary Syndrome (PCOS): A 21-Year Follow-Up Study of Women Diagnosed with PCOS around 50 Years Ago and Their Age-Matched Controls. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96:2178-2185(2011).
