SFTPA1
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Official Full Name
surfactant protein A1 -
Overview
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The;encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This;protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations;in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript;variants. -
Synonyms
SFTPA1;SPA;PSAP;PSPA;SP-A;SPA1;PSP-A;SFTP1;SP-A1;COLEC4;SFTPA1B;pulmonary surfactant-associated protein A1;collectin-4;surfactant protein A1B;alveolar proteinosis protein;surfactant protein A1 variant AD' 6A;surfactant protein A1 variant AD' 6A2;surfactant protein A1 variant AD' 6A3;surfactant protein A1 variant AD' 6A4;surfactant protein A1 variant ACD' 6A2;surfactant protein A1 variant ACD' 6A3;surfactant protein A1 variant ACD' 6A4;surfactant protein A1 variant AB'D' 6A2;surfactant protein A1 variant AB'D' 6A3;surfactant protein A1 variant AB'D' 6A4;surfactant, pulmonary-associated protein A1A;surfactant, pulmonary-associated protein A1B;35 kDa pulmonary surfactant-associated protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli expression system
- HEK293F
- Yeast
- Mamanlian cells
- His
- Myc&DDK
- GST
- His&GST
- His&T7
- His&Myc
- His&Myc&B2M
- His&SUMO
- His&Fc&Avi
- Flag
Involved Pathway
SFTPA1 involved in several pathways and played different roles in them. We selected most pathways SFTPA1 participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFTPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | RAB7A,ATP6V1C1A,HLA-DRB5,CORO1A,SEC61G,TUBA1L2,MRC2,CCDC102A,ATPV0E2,FAM49BA |
Protein Function
SFTPA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SFTPA1 itself. We selected most functions SFTPA1 had, and list some proteins which have the same functions with SFTPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SFTPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFTPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFTPA1.
Resources
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References
- Noutsios, GT; Silveyra, P; et al. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L722-L735(2013).
